Review: Misoprostol or COX-2-specific or selective NSAIDs reduce gastrointestinal complications and symptomatic ulcers

May 2005
ACP Journal Club;May/Jun2005, Vol. 142 Issue 3, p75
Academic Journal
This article presents a study, which reports that Misoprostol or COX-2-specific or selective non-steroidal anti-inflammatory drugs (NSAID) reduce gastrointestinal (GI) complications and symptomatic ulcers. The study method consisted of randomized controlled trials for 21 days in duration comparing 1 of the 5 gastroprotective strategies with nonselective NSAIDs alone on outcomes of GI toxicity. The primary outcomes included serious GI complications, such as hemorrhage, hemorrhagic erosions, recurrent upper GI bleeding, perforation and pyloric obstruction and symptomatic ulcers.


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