Intradermal injection of reduced-dose influenza vaccine was highly immunogenic in persons ⩽60 years of age but less so in persons >60 years: COMMENTARY

Langley, Joanne M.
May 2005
ACP Journal Club;May/Jun2005, Vol. 142 Issue 3, p68
Academic Journal
The article comments on the previous review which focused on the intradermal injection of reduced-dose influenza vaccine. In the studies by previous researchers low doses of inactivated influenza vaccines, licensed for intramuscular injection, were delivered to healthy participants by the intradermal route. This route of antigen delivery is known to engage the dendritic cell, a potent antigen-presenting cell located in peripheral tissues that links the innate arm of the immune system with the cellular and humoral arms. Dendritic-cell-based vaccination strategies have been explored for several infectious agents and have become an exciting new pathway for vaccine development and immune intervention.


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