Review: Bupropion and nortriptyline each increase smoking cessation rates

May 2005
ACP Journal Club;May/Jun2005, Vol. 142 Issue 3, p67
Academic Journal
This article reports that bupropion and nortriptyline each increase smoking cessation rates. The study sought to find out whether antidepressants increase long-term abstinence from smoking. Randomized controlled trials (RCTs) compared any antidepressant with placebo or another treatment and assessed smoking abstinence at ≥ 6 months. Studies were pooled using fixed effects. It was found that in smokers, bupropion and nortriptyline increase smoking cessation at ≥ 6 months. Selective serotonin-reuptake inhibitors do not increase abstinence.


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