Trandolapril did not reduce cardiovascular death or other events in stable coronary artery disease: COMMENTARY

Granger, Christopher B.
May 2005
ACP Journal Club;May/Jun2005, Vol. 142 Issue 3, p66
Academic Journal
This article reports that the PEACE trial, the latest in a trifecta of trials evaluating ACE inhibitors for patients who have cardiovascular disease without heart failure, did not show a benefit of trandolopril in patients with coronary aretery disease at low risk for complications. These results were surprising in light of the other trials, and the qualitatively different findings provide important information to clinicians. Possible explanations for the difference include the drug (including dose and compliance), the patient population, and chance. The authors carefully considered these possibilities and showed that compliance was only slightly lower than in other trials and that the drug and its dose had a clear biological effect in PEACE.


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