Diuretic-based therapy reduced cardiovascular mortality in older patients with isolated systolic hypertension and diabetes: COMMENTARY

Alkhenizan, Abdullah
May 2005
ACP Journal Club;May/Jun2005, Vol. 142 Issue 3, p64
Academic Journal
This article cites a medical research which reports the long-term effects of diuretic-based therapy in the SHEP trial. During the extended 10-year follow-up, diuretic-based therapy was associated with a lower rate of cardiovascular mortality, which was not observed during the 4.3-year double-blind phase of the study. These results add more support to the JNC VII recommendation to use thiazide-type diuretics as the initial therapy for uncomplicated hypertension. It is clear from recent, large hypertension trials that several newer classes of drugs reduce the complications of hypertension and can be used as first-line therapy, but diuretics are as effective and cost less.


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