Review: Insulin monotherapy and insulin combined with oral hypoglycemic agents provide similar glycemic control

May 2005
ACP Journal Club;May/Jun2005, Vol. 142 Issue 3, p62
Academic Journal
The article cites a medical study which reports that insulin monotherapy and insulin combined with oral hypoglycemic agents provide similar glycemic control. Randomized controlled trials (RCTs) with ≥ 2-month follow-up compared insulin monotherapy with combinations of insulin and single or multiple OHAs in patients with type 2 diabetes and inadequate glycemic control. Study quality was assessed using the Maastricht-Amsterdam Criteria List, which considered randomization procedure, allocation concealment, blinding, withdrawals and dropouts, and intention-to-treat analysis (total score range 0 to 7).


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