Picotamide reduced all-cause mortality more than aspirin in type 2 diabetes mellitus and peripheral arterial disease: COMMENTARY

Smith, Donald A.
May 2005
ACP Journal Club;May/Jun2005, Vol. 142 Issue 3, p61
Academic Journal
This article comments on the effect of picotamide in type 2 diabetes mellitus and peripheral arterial disease. The 24-month DAVID study by Neri Serneri and colleagues compared picotamide with daily aspirin in patients with type 2 diabetes and PAD, and showed a decreased risk for all-cause mortality. The only disappointing finding was the nonsignificant reduction of the composite endpoint of mortality and nonfatal cardiovascular events. This leaves the interpretation difficult and a need for further confirmatory trials. If proven equivalent to or better than aspirin in CV prevention, picotamide will be a welcome addition to calm the hyperactive platelets in diabetic patients.


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