TITLE

Review: Atenolol may be ineffective for reducing cardiovascular morbidity or all-cause mortality in primary hypertension: COMMENTARY

AUTHOR(S)
Cruickshank, J. Kennedy
PUB. DATE
May 2005
SOURCE
ACP Journal Club;May/Jun2005, Vol. 142 Issue 3, p59
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article comments on the study on cardiovascular morbidity in primary hypertension. Preliminary results from the large ASCOT open-label trial were recently presented to the American College of Cardiology Annual Scientific Session (3); some 19 000 higher-risk patients with hypertension were randomized to atenolol 50 to 100 mg, then bendrofluazide 1.25 to 2.5 mg if needed, or to amlodipine 5 to 10 mg, then perindopril 4 to 8 mg per day if needed. In summary, the meta-analysis by researchers and newer data suggest that atenolol, when used as first-line therapy for hypertension, is inferior to several other medications.
ACCESSION #
17116515

 

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