Review: Implantable Cardioverter defibrillators reduce all-cause mortality in nonischemic cardiomyopathy: COMMENTARY

Hernandez, Adrian F.
May 2005
ACP Journal Club;May/Jun2005, Vol. 142 Issue 3, p57
Academic Journal
This article states that fatal arrhythmias cause a substantial portion of deaths in nonischemic heart failure. However, previous studies of Implantable cardioverter defibrillators have mainly focused on patients with ischemic heart failure. The meta-analysis by researchers is timely because it examined whether an ICD reduces all-cause mortality in patients with nonischemic cardiomyopathy. Although it is preferable to make decisions using evidence from pivotal RCTs of the population in question, the use of a meta-analysis helps in situations exactly like this — a highly important observed risk and an intervention proven to be effective elsewhere yet less definitive in individual studies because of small subgroup sample sizes.


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