Association of a polymorphism of the transforming growth factor-β1 gene with cerebral amyloid angiopathy

Hamaguchi, T.; Okino, S.; Sodeyama, N.; Itoh, Y.; Takahashi, A.; Olomo, E.; M.Matsushha; Mizusawa, H.; Yamada, M.
May 2005
Journal of Neurology, Neurosurgery & Psychiatry;May2005, Vol. 76 Issue 5, p696
Academic Journal
Background: A recent study showed that transforming growth factor-β1 (TGF-β1) induces amyloid-β deposition in cerebral blood vessels and meninges of a transgenic mouse model of Alzheimer's disease (AD), and that TGF-β1 mRNA levels are correlated with cerebral amyloid angiopathy (CAA) in human AD brains. A T/C polymorphism at codon 10 in exon 1 of the TGF-β1 gene has been reported to be associated with the serum TGF-β1 concentration. We investigated whether the TGF-β1 polymorphism is associated with the risk of CAA. Methods: The association between the severity of CAA and the T/C polymorphism at codon 10 in exon 1 of the TGF-β1 was investigated in 167 elderly Japanese autopsy cases, including 73 patients with AD. The apolipoprotein E (APOE) genotype was also determined. Results: The genotypes (TT/TC/CC) were associated with the severity of CAA significantly in all patients (p = 0.0026), in non-AD patients (p = 0.011), and APOE non-ϵ4 carriers (p = 0.0099), but not in AD patients or APOE ϵ4 carriers. The number of the T alleles positively correlated with the severity of CAA in all patients (p = 0.0011), non-AD patients (p = 0.0026 ), and APOE non-ϵ4 carriers (p = 0.0028), but not in AD patients or APOE ϵ4 carriers. The polymorphism was not significantly associated with AD. Conclusions: Our results suggest that the polymorphism in TGF-β1 is associated with the severity of CAA, especially in non-AD patients and APOE non-ϵ carriers.


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