TITLE

The impact of ibuprofen on renal clearance in preterm infants is independent of the gestational age

AUTHOR(S)
Allegaert, Karel; Cossey, Veerle; Debeer, Anne; Langhendries, Jean Paul; van Overmeire, Bart; de Hoon, Jan; Devlieger, Hugo
PUB. DATE
June 2005
SOURCE
Pediatric Nephrology;Jun2005, Vol. 20 Issue 6, p740
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of this investigation was to evaluate whether the relative change in renal clearance due to ibuprofen administration depends on the gestational age (GA). Clearance of amikacin was used as a surrogate marker for renal clearance in preterm infants (GA 24–34 weeks, day 1) on respiratory support. Clearance in infants co-treated with ibuprofen was compared to that of infants not co-treated with ibuprofen. Absolute change of clearance in four consecutive cohorts of increasing (<27, 27–28, 29–31, 32–34 weeks) GA and linear correlations of clearance on GA were calculated in both groups. Data were collected from 204 infants, of whom 93 were co-treated with ibuprofen. Mean amikacin clearance was lower (0.48 to 0.59 ml/kg/min, P<0.001) in infants co-treated with ibuprofen. Absolute decrease in mean amikacin clearance (0.10 to 0.14 ml/kg/min) was similar in all four cohorts. Linear correlations of clearance with GA were documented in infants co-treated (y =0.21+0.011x) or not co-treated (y =0.44+0.009x) with ibuprofen. Renal clearance, reflected by amikacin clearance, is decreased by ibuprofen in preterm infants of 24 to 34 weeks GA on respiratory support on the 1st day of life, independent of the GA.
ACCESSION #
17011388

 

Related Articles

  • Ibuprofen Lysinate and sodium ibuprofen for prophylaxis of patent ductus arteriosus in preterm neonates. Carolis, Maria; Bersani, I.; Rosa, G.; Cota, F.; Romagnoli, C. // Indian Pediatrics;Jan2012, Vol. 49 Issue 1, p47 

    This retrospective, study compared the efficacy and safety of Ibuprofen-Lysinate (Arfen, intramuscular formulation, Group I, n=156) used during 2000-2005 and Sodium-ibuprofen (Pedea, intravenous solution, Group II, n=60) used during 2006-2008, for the prophylaxis of Patent Ductus Arteriosus in...

  • Changes in quantitative ultrasound in infants born at less than 32 weeks' gestation over the first 2 years of life: influence of clinical and biochemical changes. McDevitt, H.; Tomlinson, C.; White, M.; Ahmed, S.; White, M P; Ahmed, S F // Calcified Tissue International;Oct2007, Vol. 81 Issue 4, p263 

    Studies in preterm infants show reduced speed of sound (SOS) as measured by quantitative ultrasound (QUS) during the immediate neonatal period. There is a scarcity of data on SOS changes following hospital discharge. The aim of this study was to assess SOS over the first 2 years in preterm...

  • Development of baroreflex control of heart rate in pretem and full term infants. Gournay, V.; Drouin, E.; Rozé, J-C. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;May2002, Vol. 86 Issue 3, pF151 

    Aim: To study baroreflex maturation by measuring, longitudinally, baroreflex sensitivity in preterm (gestational age 24-37 weeks) and full term infants. Methods: Baroreflex sensitivity was quantified once a week, one to seven times, by a totally non-invasive method. Results: Baroreflex...

  • Randomised trial of parental support for families with very preterm children: outcome at 5 years. Johnson, S.; Ring, W.; Anderson, P.; Marlow, N. // Archives of Disease in Childhood;Sep2005, Vol. 90 Issue 9, p909 

    Aims: To test the effectiveness of a home based developmental education intervention in improving outcome at 5 years for very preterm infants. Methods: The Avon Premature Infant Project (APIP) is a randomised controlled trial in which the parents of 284 babies born <33 weeks gestational age...

  • Kidney development in the first year of life in small-for-gestational-age preterm infants. Hotoura, Efthalia; Argyropoulou, Maria; Papadopoulou, Frederica; Giapros, Vasilios; Drougia, Aikaterini; Nikolopoulos, Panayiotis; Andronikou, Styliani // Pediatric Radiology;Oct2005, Vol. 35 Issue 10, p991 

    Background: Small-for-gestational-age (SGA) infants have been reported to have a significantly reduced number of nephrons that could be a risk factor for development of hypertension later in life.Objective: To evaluate kidney size prospectively in relation to other...

  • A gestation- and postnatal age-based reference chart for assessing renal function in extremely premature infants. Thayyil, S.; Sheik, S.; Kempley, S. T.; Sinha, A. // Journal of Perinatology;Mar2008, Vol. 28 Issue 3, p226 

    Objective:A single value of plasma creatinine cannot be used to define renal dysfunction in premature babies, as levels are influenced by gestation and postnatal age. The aim of this study was to create reference ranges for plasma creatinine in cohort of extremely premature infants.Study...

  • Sodium and potassium clearances by the maturing kidney: clinical-molecular correlates. Delgado, Mercedes M.; Rohatgi, Rajeev; Khan, Shahana; Holzman, Ian R.; Satlin, Lisa M. // Pediatric Nephrology;Aug2003, Vol. 18 Issue 8, p759 

    A temporal dissociation exists between the early appearance of sodium absorptive and later detection of potassium secretory processes in the maturing rabbit collecting duct. To extend the latter findings to the human, we sought to correlate developmental changes in renal sodium and potassium...

  • Inhaled Nitric Oxide for Oligohydramnios-Induced Pulmonary Hypoplasia: A Report of Two Cases and Review of the Literature. Geary, Cara; Whitsett, Jeffrey // Journal of Perinatology;Jan2002, Vol. 22 Issue 1, p82 

    We describe the clinical courses of two premature infants, a male born at 29[SUP4/7] weeks' gestational age after an 8-week period of rupture of membranes (ROM) and severe oligohydramnios, and a female infant born at 31 weeks' gestational age after an 18-week period of ROM and severe...

  • Is the prophylaxis of patent ductus arteriosus useful in extremely premature infants? Bersani, Iliana; De Carolis, Maria Pia; Lacerenza, Serafina; De Rosa, Gabriella; Fusco, Francesca Paola; Cota, Francesco; Romagnoli, Costantino // Turkish Journal of Pediatrics;Mar/Apr2011, Vol. 53 Issue 2, p187 

    This study was aimed to verify the efficacy and safety of ibuprofen prophylaxis of patent ductus arteriosus in very preterm infants, in order to select infants receiving higher benefits from this intervention. Two hundred neonates with gestational age (GA) ≤28 weeks receiving ibuprofen...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics