TITLE

Rad50 connects by hook or by crook

AUTHOR(S)
Lichten, Michael
PUB. DATE
May 2005
SOURCE
Nature Structural & Molecular Biology;May2005, Vol. 12 Issue 5, p392
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Discusses the role of the Mre11 protein complex in maintaining genome stability. Importance of the inter-molecular bridging by the Rad50 protein on the complex’s function; Systems contained in eukaryotes that respond to double-strand DNA breaks; Components of Rad50.
ACCESSION #
16953731

 

Related Articles

  • Crystal structure of a Rad51 filament. Conway, Adam B.; Lynch, Thomas W.; Zhang, Ying; Fortin, Gary S.; Fund, Cindy W.; Symington, Lorraine S.; Rice, Phoebe A. // Nature Structural & Molecular Biology;Aug2004, Vol. 11 Issue 8, p791 

    Rad51, the major eukaryotic homologous recombinase, is important for the repair of DNA damage and the maintenance of genomic diversity and stability. The active form of this DNA-dependent ATPase is a helical filament within which the search for homology and strand exchange occurs. Here we...

  • ATM mediates interdependent activation of p53 and ERK through formation of a ternary complex with p-p53 and p-ERK in response to DNA damage. Heo, Jee-In; Oh, Soo-Jin; Kho, Yoon-Jung; Kim, Jeong-Hyeon; Kang, Hong-Joon; Park, Seong-Hoon; Kim, Hyun-Seok; Shin, Jong-Yeon; Kim, Min-Ju; Kim, Minju; Kim, Sung; Park, Jae-Bong; Kim, Jaebong; Lee, Jae-Yong // Molecular Biology Reports;Aug2012, Vol. 39 Issue 8, p8007 

    DNA damage in eukaryotic cells induces signaling pathways mediated by the ATM, p53 and ERK proteins, but the interactions between these pathways are not completely known. To address this issue, we performed a time course analysis in human embryonic fibroblast cells treated with DNA-damaging...

  • The Yeast Histone Chaperone Chromatin Assembly Factor 1 Protects Against Double-Strand DNA-Damaging Agents. Linger, Jeffrey; Tyler, Jessica K. // Genetics;Dec2005, Vol. 171 Issue 4, p1513 

    The removal of histones from DNA and their subsequent replacement is likely to be necessary for all processes that require access to the DNA sequence in eukaryotic cells. The histone chaperone chromatin assembly factor 1 (CAF-1) mediates histone H3-H4 assembly during DNA replication and...

  • In the End, it's all Structure. Crabbe, Laure; Karlseder, Jan // Current Molecular Medicine;Mar2005, Vol. 5 Issue 2, p135 

    Chromosome end protection is essential for all organisms with linear genomes. Specialized structures, called telomeres, accomplish this protection by forming DNA-protein complexes that hide the natural chromosome ends from the DNA damage machinery. In mammalian cells protection takes place on...

  • CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Kalay, Ersan; Yigit, Gökhan; Aslan, Yakup; Brown, Karen E.; Pohl, Esther; Bicknell, Louise S.; Kayserili, Hülya; Yun Li; Tüysüz, Beyhan; Nürnberg, Gudrun; Kiess, Wieland; Koegl, Manfred; Baessmann, Ingelore; Buruk, Kurtulus; Toraman, Bayram; Kayipmaz, Saadettin; Kul, Sibel; Ikbal, Mevlit; Turner, Daniel J.; Taylor, Martin S. // Nature Genetics;Jan2011, Vol. 43 Issue 1, p23 

    Functional impairment of DNA damage response pathways leads to increased genomic instability. Here we describe the centrosomal protein CEP152 as a new regulator of genomic integrity and cellular response to DNA damage. Using homozygosity mapping and exome sequencing, we identified CEP152...

  • DNA REPAIR: Damage control. Frantz, Simon // Nature Reviews Molecular Cell Biology;Dec2001, Vol. 2 Issue 12, p870 

    Discusses research on the mechanisms involved in recognizing DNA damage. Reference to a study by Katsunori Sugimoto and colleagues published in "Science" journal; Response of eukaryotic cells to DNA damage; Recruitment mechanisms of the gene product in DNA damage.

  • Non-coding RNAs in DNA damage response. Yunhua Liu; Xiongbin Lu // American Journal of Cancer Research;2012, Vol. 2 Issue 6, p658 

    Genome-wide studies have revealed that human and other mammalian genomes are pervasively transcribed and produce thousands of regulatory non-protein-coding RNAs (ncRNAs), including miRNAs, siRNAs, piRNAs and long non-coding RNAs (lncRNAs). Emerging evidences suggest that these ncRNAs also play a...

  • Safeguarding genetic information in Drosophila. Su, Tin // Chromosoma;Dec2011, Vol. 120 Issue 6, p547 

    Eukaryotic cells employ a plethora of conserved proteins and mechanisms to ensure genome integrity. In metazoa, these mechanisms must operate in the context of organism development. This mini-review highlights two emerging features of DNA damage responses in Drosophila: a crosstalk between DNA...

  • DNA damage checkpoint in budding yeast. Longhese, Maria Pia; Foiani, Marco; Muzi-Falconi, Marco; Lucchini, Giovanna; Plevani, Paolo // EMBO Journal;10/1/98, Vol. 17 Issue 19, p5525 

    Eukaryotic cells have evolved a network of control mechanisms, known as checkpoints, which coordinate cell-cycle progression in response to internal and external cues. The yeast Saccharomyces cerevisiae has been invaluable in dissecting genetically the DNA damage checkpoint pathway. Recent...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics