Gaisböck's Syndrome: Its Hematologic, Biochemical and Hormonal Parameters

Stefanini, Mario; Urbas, John V.; Urbas, John E.
July 1978
Angiology;Jul1978, Vol. 29 Issue 7, p520
Academic Journal
The syndrome of plethora without splenomegaly% leukocytosis, or thrombocytosis was described by Gaisböck in 1 905. it was reevaluated in 25 patients through the study of numerous hematologic and biochemical part meters. Statistically significant findings included mild obesity: elevation of blood pressure (especially diastolic); decrease in plasma volume with relative increase in red cell count, hemoglobin, hematocrit, viscosity of blood, elevation of plasma proteins, serum cholesterol, triglycerides, uric acid, and plasma renin: and increased excretion of urinary sodium. The reduction in plasma volume seemed related to the elevation of the diastolic blood pressure, arid favorable through temporary therapeutic results were produced by sonic antihypertensive agents. The elevation of serum cholesterol, triglycerides, and uric acid, he increased blood Viscosity, and the elevated plasma renin were reminescent of he biochemical changes observed in sonic instances of hypertension and atherosclerosis disease. They may explain why patients with the Gaishöck's syndrome belong to the high risk group of hypertensive individuals who often develop cardiovascular complications. While its' long-term effects remain to be evaluated. treatment with nondiuretic antihypertensive drugs may help reduce the incidence of these complications.


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