Knisely, Melvin H.; Warner, Louise; Harding, Fann
December 1960
Angiology;Dec1960 Part 2, Vol. 11 Issue 6, p535
Academic Journal
Methods have been developed for studying the physics of the flow of normal and pathologic blood in vivo. A number of factors which contribute to the settling of masses of agglutinated blood cells to the lower sides of vessels during life have been determined experimentally. Some of these are biologic factors; some are physical factors. The study of the circulation of normal and pathologic blood through a horizontal microscope provides a whole new mental point of view from which to examine quite a number of phenomena. The methods described make it possible to carry out directly observed experiments to find out whether the settling of blood-cell masses is a part of the pathologic physiology of each known type of secondary circulatory shock. They make possible the direct observation of the formation of venous thrombi in vivo. With these and accessory methods, the experimental control of known and suspected variables acting either to initiate or to prevent venous thrombosis can be maintained. Thus, the various different Bets of processes which lead to venous thrombosis (of which most have heretofore been hidden from view and obscure) are now open to direct observation and experimental analysis.


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