Neurobehavioral effects of treatment for opiate withdrawal

Coyle, M. G.; Ferguson, A.; LaGasse, L.; Liu, J.; Lester, B.
January 2005
Archives of Disease in Childhood -- Fetal & Neonatal Edition;Jan2005, Vol. 90 Issue 1, pF73
Academic Journal
A partially randomised, controlled trial was performed to test the hypothesis that opiate exposed infants treated with diluted tincture of opium (DTO) and phenobarbital would have better neurobehavioral scores than infants treated with DTO atone. Compared with those treated with DTO atone (n = 15), infants treated with DTO and phenobarbital (n = 17) were more interactive, had smoother movements, were easier to handle, and less stressed. Dual treatment results in improved neurobehavioral organisation during the first three weeks of life, which may indicate a more rapid recovery from opiate withdrawal.


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