TITLE

White matter hyperintensities are related to physical disability and poor motor function

AUTHOR(S)
Sachdev, P. S.; Wen, W.; Christensen, H.; Jorm, A. F.
PUB. DATE
March 2005
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Mar2005, Vol. 76 Issue 3, p362
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Objective: To determine the impact of white matter hyperintensities (WMHs) on physical health and cognitive function in 60-64 year old individuals residing in the community.Methods: A subsample of 478 persons aged 60-64 from a larger community sample underwent brain magnetic resonance imaging (MRI) scans. WMHs on T2 weighted FLAIR (fluid attenuated inversion recovery) MRI scans were assessed using an automated procedure. Subjects were assessed for global cognitive function, episodic memory, working memory (digit span), information processing speed (Symbol Digit Modalities Test; SDMT), fine motor dexterity (Purdue Pegboard), and grip strength, and completed the Physical Component Summary of the Short Form Health Survey (SF-12). Regression analyses were used to examine the effect of WMHs on physical and cognitive function.Results: Deep and periventricular WMHs were present in all subjects, with women having slightly more lesions than men. WMHs were significantly associated with poorer reported physical health on the SF-12 scale, after adjusting for depression, cognitive function, and brain atrophy. WMHs were also related to lower scores on the Purdue Pegboard test, grip strength, choice reaction time, and SDMT, but not on tests of episodic memory, working memory, general intellectual function, and global cognitive function. On regression analyses, the Purdue Pegboard test and grip strength were related to physical disability.Conclusion: WMHs are common, albeit mild, in middle adult life. They are associated with physical disability, possibly through reduced speed, fine motor coordination, and muscular strength. They are also related to slowed information processing speed but not other cognitive functions.
ACCESSION #
16911293

 

Related Articles

  • Are Structural Changes Induced by Lithium in the HIV Brain Accompanied by Changes in Functional Connectivity? Tivarus, Madalina E.; Pester, Britta; Schmidt, Christoph; Lehmann, Thomas; Zhu, Tong; Zhong, Jianhui; Leistritz, Lutz; Schifitto, Giovanni // PLoS ONE;10/5/2015, Vol. 10 Issue 10, p1 

    Lithium therapy has been shown to affect imaging measures of brain function and microstructure in human immunodeficiency virus (HIV)-infected subjects with cognitive impairment. The aim of this proof-of-concept study was to explore whether changes in brain microstructure also entail changes in...

  • Does Sleep Deprivation Impair Orthopaedic Surgeons' Cognitive and Psychomotor Performance? O'Brien, Michael J.; O'Toole, Robert V.; Newell, Mary Zadnik; Lydecker, Alison D.; Nascone, Jason; Sciadini, Marcus; Pollak, Andrew; Turen, Clifford; Eglseder, W. Andrew // Journal of Bone & Joint Surgery, American Volume;11/7/2012, Vol. 94-A Issue 21, p1975 

    Background: Sleep deprivation may slow reaction time, cloud judgment, and impair the ability to think. Our purpose was to study the cognitive and psychomotor performances of orthopaedic trauma surgeons on the basis of the amount of sleep that they obtained. Methods: We prospectively studied the...

  • 41: Scans Unlock Hidden Life in Vegetative Brains. MCGOWAN, KAT // Discover;Jan/Feb2011, Vol. 32 Issue 1, p54 

    The article discusses research by neuroscientists Adrian Owen, Martin Monti, and others reported in the February 2010 issue of the "New England Journal of Medicine" on the use of functional magnetic resonance imaging in evaluating the cognitive function of a brain-damaged car accident victim.

  • Whole Brain Magnetic Resonance Image Atlases: A Systematic Review of Existing Atlases and Caveats for Use in Population Imaging. Dickie, David Alexander; Shenkin, Susan D.; Anblagan, Devasuda; Juyoung Lee; Cabez, Manuel Blesa; Rodriguez, David; Boardman, James P.; Waldman, Adam; Job, Dominic E.; Wardlaw, Joanna M. // Frontiers in Neuroinformatics;1/19/2017, Vol. 11, p1 

    Brain MRI atlases may be used to characterize brain structural changes across the life course. Atlases have important applications in research, e.g., as registration and segmentation targets to underpin image analysis in population imaging studies, and potentially in future in clinical practice,...

  • Multi-modal representation of effector modality in frontal cortex during rule switching. Hodgson, Timothy L.; Parris, Benjamin A.; Benattayallah, Abdelmalek; Summers, Ian R. // Frontiers in Human Neuroscience;Sep2015, Vol. 9, p1 

    We report a functional magnetic resonance imaging (fMRI) study which investigated whether brain areas involved in updating task rules within the frontal lobe of the cerebral cortex show activity related to the modality of motor response used in the task. Participants performed a rule switching...

  • BDNF increases homotypic olivocerebellar reinnervation and associated fine motor and cognitive skill. Melina L. Willson; Catriona McElnea; Jean Mariani; Ann M. Lohof; Rachel M. Sherrard // Brain: A Journal of Neurology;Apr2008, Vol. 131 Issue 4, p1099 

    Recovery of complex neural function after injury to the adult CNS is limited by minimal spontaneous axonal regeneration and/or sprouting from remaining pathways. In contrast, the developing CNS displays spontaneous reorganization following lesion, in which uninjured axons can develop new...

  • Social cognitive development during adolescence. Choudhury, Suparna; Blakemore, Sarah-Jayne; Charman, Tony // Social Cognitive & Affective Neuroscience;Dec2006, Vol. 1 Issue 3, p165 

    Social relationships are particularly important during adolescence. In recent years, histological and MRI studies have shown that the brain is subject to considerable structural development during adolescence. Brain regions that are implicated in social cognition, including parts of prefrontal,...

  • Neural mechanisms underlying the effects of face-based affective signals on memory for faces: a tentative model. Takashi Tsukiura // Frontiers in Integrative Neuroscience;Jul2012, Vol. 6, p1 

    In our daily lives, we form some impressions of other people. Although those impressions are affected by many factors, face-based affective signals such as facial expression, facial attractiveness, or trustworthiness are important. Previous psychological studies have demonstrated the impact of...

  • Monitoring attentional state with fNIRS. Harrivel, Angela R.; Weissman, Daniel H.; Noll, Douglas C.; Peltier, Scott J. // Frontiers in Human Neuroscience;Dec2013, Vol. 7, p1 

    The ability to distinguish between high and low levels of task engagement in the real world is important for detecting and preventing performance decrements during safety-critical operational tasks. We therefore investigated whether functional Near Infrared Spectroscopy (fNIRS), a portable brain...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics