TITLE

Angiotensin-Converting Enzyme Inhibitor (SQ 20881) in the Diagnosis of Renovascular Hypertension

AUTHOR(S)
Rosenthal, T.; Kissin, E.; Jacob, E. T.; Stern, N.; Levi, Y.; Adar, R.
PUB. DATE
February 1979
SOURCE
Angiology;Feb1979, Vol. 30 Issue 2, p123
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
SQ 20881 all angiotensin-converting enzyme inhibitor, was given to 12 patients with renovascular hypertension and to 1 patient with unilateral parenchymatous renal disease in order to evaluate the role of renin-angiotensin systems in their hypertension. Plasma renin activity (PRA ) and aldosterone were assayed in systemic blood before arid after the injection of SQ 20881 . In 5 patients PRA was also measured separately in each renal vein. Blood pressure decreased. PRA increased, and aldosterone level decreased in the 12 renin-dependant patients. When PRA was sampled separately From each renal vein, the increase was larger on the side of the affected kidney. Four patients with a positive test underwent corrective surgery, and in all blood pressure became normal. SQ 20881 is a useful agent in evaluating the contribution of renin in patients with hypertension.
ACCESSION #
16902482

 

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