Plasminogen and Moderate Doses of Urokinase in the Treatment of Acute Pulmonary Embolism

Griguer, P.; Charbonnier, B.; Latour, F.; Fauchier, J. P.; Brochier, Mireille
January 1979
Angiology;Jan1979, Vol. 30 Issue 1, p1
Academic Journal
This article focuses on the use of plasminogen and moderate doses of urokinase in the treatment of acute pulmonary embolism (PE). Urokinase (UK) at moderate doses has proved in the authors' first series of 80 patients to be as effective as urokinase at high doses in the treatment of massive or severe pulmonary embolism. Experiments have shown that 35,000 CTA units of UK per hour are enough to develop fibrinolytic activity in the plasma, resulting in the rapid lysis of artificial clots. The results of the treatment of PE vary considerably as far as mortality is concerned.


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