How an imprint can lead to cancer

Secko, David
May 2005
CMAJ: Canadian Medical Association Journal;5/10/2005, Vol. 172 Issue 10, p1286
Academic Journal
Discusses research being done on the link between mutations in parental imprinting and cancer. Reference to a study by A. P. Feinberg and B. Tycko; Focus of the etiology of cancer; Effect of methyl groups on DNA; Influence of mutations in parental imprinting on cell differentiation.


Related Articles

  • Strategies for Detecting Genomic DNA Methylation: A Survey of US Patents. Chaudhry, M. Ahmad // Recent Patents on DNA & Gene Sequences;Jun2010, Vol. 4 Issue 2, p79 

    DNA methylation is one of the mechanisms for the epigenetic control of gene expression. Alterations in the methylation status of genomic DNA can result in the silencing of genes. Such control is of significance for a wide range of biological processes, ranging from cellular differentiation...

  • Ubiquitination/deubiquitination and acetylation/deacetylation: Making DNMT1 stability more coordinated. Hong, Qi; Shao, Zhi-ming // Acta Pharmacologica Sinica;Feb2011, Vol. 32 Issue 2, p139 

    No abstract available.

  • A Bayesian Method for Simultaneously Detecting Mendelian and Imprinted Quantitative Trait Loci in Experimental Crosses of Outbred Species. Hayashi, Takeshi; Awata, Takashi // Genetics;Jan2008, Vol. 178 Issue 1, p527 

    Genomic imprinting is interpreted as a phenomenon, in which some genes inherited from one parent are not completely expressed due to modification of the genome caused during gametogenesis. Subsequently, the expression level of an allele at the imprinted gene is changed dependent on the parental...

  • The Application of Restriction Landmark Genome Scanning Method for Surveillance of Non-Mendelian Inheritance in F1 Hybrids. Takamiya, Tomoko; Hosobuchi, Saeko; Noguchi, Tomotsugu; Paterson, Andrew H.; Iijima, Hiroshi; Murakami, Yasufumi; Okuizumi, Hisato // Comparative & Functional Genomics;2009, Special section p1 

    We analyzed inheritance of DNA methylation in reciprocal F1 hybrids (subsp. japonica cv. Nipponbare × subsp. indica cv. Kasalath) of rice (Oryza sativa L.) using restriction landmark genome scanning (RLGS), and detected differing RLGS spots between the parents and reciprocal F1 hybrids....

  • BisoGenet: a new tool for gene network building, visualization and analysis. Martin, Alexander; Ochagavia, Maria E.; Rabasa, Laya C.; Miranda, Jamilet; Fernandez-de-Cossio, Jorge; Bringas, Ricardo // BMC Bioinformatics;2010, Vol. 11, p91 

    Background: The increasing availability and diversity of omics data in the post-genomic era offers new perspectives in most areas of biomedical research. Graph-based biological networks models capture the topology of the functional relationships between molecular entities such as gene, protein...

  • Hypomethylation at multiple maternally methylated imprinted regions including PLAGL1 and GNAS loci in Beckwith—Wiedemann syndrome. Bliek, Jet; Verde, Gaetano; Callaway, Jonathan; Maas, Saskia M.; De Crescenzo, Agostina; Sparago, Angela; Cerrato, Flavia; Russo, Silvia; Ferraiuolo, Serena; Rinaldi, Maria Michela; Fischetto, Rita; Lalatta, Faustina; Giordano, Lucio; Ferrari, Paola; Cubellis, Maria Vittoria; Larizza, Lidia; Temple, I. Karen; Mannens, Marcel M. A. M.; Mackay, Deborah J. G.; Riccio, Andrea // European Journal of Human Genetics;May2009, Vol. 17 Issue 5, p611 

    Genomic imprinting is an epigenetic phenomenon restricting gene expression in a manner dependent on parent of origin. Imprinted gene products are critical regulators of growth and development, and imprinting disorders are associated with both genetic and epigenetic mutations, including...

  • MPprimer: a program for reliable multiplex PCR primer design. Zhiyong Shen; Wubin Qu; Wen Wang; Yiming Lu; Yonghong Wu; Zhifeng Li; Xingyi Hang; Xiaolei Wang; Dongsheng Zhao; Chenggang Zhang // BMC Bioinformatics;2010, Vol. 11, p143 

    Background: Multiplex PCR, defined as the simultaneous amplification of multiple regions of a DNA template or multiple DNA templates using more than one primer set (comprising a forward primer and a reverse primer) in one tube, has been widely used in diagnostic applications of clinical and...

  • Multiconstrained gene clustering based on generalized projections. Jia Zeng; Shanfeng Zhu; Alan Wee-Chung Liew; Hong Yan // BMC Bioinformatics;2010, Vol. 11, p164 

    Background: Gene clustering for annotating gene functions is one of the fundamental issues in bioinformatics. The best clustering solution is often regularized by multiple constraints such as gene expressions, Gene Ontology (GO) annotations and gene network structures. How to integrate multiple...

  • Analysis of candidate imprinted genes linked to Dlk1-Gtl2 using a congenic mouse line. Yevtodiyenko, Aleksey; Carr, Michael S.; Patel, Nafisa; Schmidt, Jennifer V. // Mammalian Genome;Nov2002, Vol. 13 Issue 11, p633 

    The study of genomic imprinting requires the use of DNA sequence polymorphisms between interfertile mouse species or strains. Most commonly, crosses between Mus musculus domesticus and Mus musculus castaneus or Mus spretus animals are used. Difficulties arise in the maintenance of these...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics