Pulmonary tuberculosis and extreme prematurity

Katumba-Lunyenya, J.; Joss, V.; Latham, P.; Abbatuan, C.; Hurley, P.; isaacs, D.; Pollard, A. J.; Elias-Jones, A. C.; Larcher, V.
March 2005
Archives of Disease in Childhood -- Fetal & Neonatal Edition;Mar2005, Vol. 90 Issue 2, pF178
Academic Journal
A mother, newly found to be positive for HIV, delivered her first baby at 25 weeks gestation. The infant initially did well in spite of a symptomatic patent duct and a severe intraventricular haemorrhage, but became severely unwell needing further respiratory support on day 18. Acid fast bacilli were found in endotracheal secretions. After the baby's death, the bacilli were confirmed to be Mycobacterium tuberculosis, and the same organism was grown from the mother's urine. The case raised challenging issues in relatively uncharted territory in terms of treatment of the infant, public health issues, ethical decision making, and media management.


Related Articles

  • Mycobacterium tuberculosis Beijing Genotype, the Netherlands. Borgdorff, Martien W.; de Haas, Petra; Kremer, Kristin; van Soolingen, Dick // Emerging Infectious Diseases;Oct2003, Vol. 9 Issue 10, p1310 

    To determine whether the Beijing genotype of Mycobacterium tuberculosis is emerging in the Netherlands, we collected data on 6,829 patients during 1993 to 2000. Six percent had the Beijing genotype. This genotype was associated with diagnosis in recent years, young age, nationality, and...

  • Tuberculosis: New Aspects of an Old Disease. Jordao, Luisa; Vieira, Otilia V. // International Journal of Cell Biology;2011, Vol. 2011, p1 

    Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. In this paper we focus on...

  • Drug Resistant Tuberculosis - Is There Hope? Goel, Manish Kumar; Khanna, Pardeep // Australasian Medical Journal;Apr2010, Vol. 3 Issue 4, p226 

    Tuberculosis remains a worldwide public health problem. India has the highest burden of tuberculosis in the world and accounts for nearly 2/5th of global burden and 2/3rd of burden in SEAR countries. The XDR- TB was first described in March 2006 and has also been reported in India. The emergence...

  • Use of interferon gamma-based assay to diagnose tuberculosis infection in health care workers after short term exposure. Storla, Dag Gundersen; Kristiansen, Ingun; Oftung, Fredrik; Korsvold, Gro Ellen; Gaupset, Monica; Gran, Gerd; Øverby, Anne Kristin; Dyrhol-Riise, Anne Margarita; Bjune, Gunnar Aksel // BMC Infectious Diseases;2009, Vol. 9 Issue 1, Special section p1 

    Background: We intended to assess the risk for health care workers (HCWs) of acquiring M. tuberculosis infection after exposure to patients with sputum-smear positive pulmonary tuberculosis at three University Hospitals (Ullevål, Akershus, and Haukeland) in Norway. Methods: We tested 155...

  • Optimisation of Bioluminescent Reporters for Use with Mycobacteria. Andreu, Nuria; Zelmer, Andrea; Fletcher, Taryn; Elkington, Paul T.; Ward, Theresa H.; Ripoll, Jorge; Parish, Tanya; Bancroft, Gregory J.; Schaible, Ulrich; Robertson, Brian D.; Wiles, Siouxsie // PLoS ONE;2010, Vol. 5 Issue 5, p1 

    Background: Mycobacterium tuberculosis, the causative agent of tuberculosis, still represents a major public health threat in many countries. Bioluminescence, the production of light by luciferase-catalyzed reactions, is a versatile reporter technology with multiple applications both in vitro...

  • Potassium uptake systems of Mycobacterium tuberculosis: genomic and protein organisation and potential roles in microbial pathogenesis and chemotherapy. Cholo, Moloko C.; Anderson, Ronald; van Rensburg, Elizabeth J. // Southern African Journal of Epidemiology & Infection;2008, Vol. 23 Issue 4, p13 

    Mycobacterium tuberculosis (MTB) is a formidable microbial pathogen which uses multiple mechanisms to subvert host immune defences. These include the effective, protective barrier presented by the outer waxy coat, intracellular concealment from host defences, and the ability to enter a...

  • Infecção por Mycobacterium tuberculosis entre agentes comunitários de saúde que atuam no controle da TB. Rodrigues, Patrícia Marques; Moreira, Tiago Ricardo; De Moraes, Andressa Karla Luz; Vieira, Rafael da Cruz Araújo; Dietze, Reynaldo; Lima, Rita de Cassia Duarte; Maciel, Ethel Leonor Noia // Jornal Brasileiro de Pneumologia;apr2009, Vol. 35 Issue 4, p351 

    Objective: To evaluate the incidence of Mycobacterium tuberculosis infection, using tuberculin skin test, among community health agents (CHAs) monitoring TB patients in the city of Cachoeiro de Itapemirim, Brazil. Methods: We included 30 CHAs acting in the Family Health Program and 30 of their...

  • Transmission of Mycobacterium tuberculosis Depending on the Age and Sex of Source Cases. Borgdorff, Martien W.; Nagelkerke, Nico J. D.; De Haas, Petra E. W.; Soolingen, Dick van // American Journal of Epidemiology;Vol. 154 Issue 10, p934 

    This study estimated to what extent tuberculosis transmission in the Netherlands depends on the age and sex of source cases. DNA fingerprints of Mycobacterium tuberculosis isolates were matched to patient information in the Netherlands Tuberculosis Register for 1993-1998. Clusters were defined...

  • Tuberculoma of the liver. Bharathi, A.; Nagarjuna, K.; Prasad, G. V. S. N.; Reddy, J. Bhaskar; Prasad, D. Kalyan Ravi // Journal of Indian Association of Pediatric Surgeons;Oct-Dec2008, Vol. 13 Issue 4, p149 

    We report an isolated giant solid macronodular tuberculoma in an 8-year-old boy. A large-space-occupying lesion in the right lobe with nodular surface and hard consistency mimicked liver malignancy. This case is unusual as the ultrasonography, computed tomography scan, and aspiration cytology...


Read the Article


Sign out of this library

Other Topics