Interferon alfa treatment for Sjogren's syndrome associated neuropathy

Yamada, S.; Mori, K.; Matsuo, K.; Inukai, A.; Kawagashira, Y.; Sobue, G.
April 2005
Journal of Neurology, Neurosurgery & Psychiatry;Apr2005, Vol. 76 Issue 4, p576
Academic Journal
journal article
Treatment response to interferon alfa (IFNalpha) is described in three consecutive cases of two forms of Sjogren's syndrome associated neuropathy (SSN)-two with sensory ataxic ganglionopathy and one with sensorimotor neuropathy with demyelinating features. All responded well to IFNalpha in terms of neuropathic symptoms, sicca symptoms, antibody titres, and findings in salivary gland biopsy specimens. IFNalpha thus showed promise in treating both SSN and the underlying Sjogren's syndrome.


Related Articles

  • Quantitative pathology of cutaneous nerve terminal degeneration in the human skin. Hsiung-Fei Chien; To-Jung Tseng; Whei-Min Lin; Chih-Chao Yang; Yang-Chyuan Chang; Rong-Chi Chen; Sung-Tsang Hsieh // Acta Neuropathologica;Nov2001, Vol. 102 Issue 5, p455 

    Pathological diagnosis of neuropathy has traditionally depended on ultrastructural examinations of nerve biopsy specimens, particularly for sensory neuropathies affecting unmyelinated and small-myelinated nociceptive nerves. These sensory nerves terminate in the epidermis of the skin, and the...

  • Early diabetic neuropathy: thermal thresholds and intraepidermal nerve fibre density in patients with normal nerve conduction studies. Løseth, Sissel; Stålberg, Erik; Jorde, Rolf; Mellgren, Svein Ivar // Journal of Neurology;Aug2008, Vol. 255 Issue 8, p1197 

    To determine whether neuropathy in diabetic patients with normal nerve conduction studies could be detected by measurements of thermal thresholds and quantification of intraepidermal nerve fibre (IENF) density, and to evaluate differences in parameters between patients with and without...

  • Peripheral neuropathy due to paclitaxel: study of the temporal relationships between the therapeutic schedule and the clinical quantitative score (QST) and comparison with neurophysiological findings. Caraceni Augusto; Miccoli Pietro; Martini Cinzia; Curzi Sergio; Cresta Sara; Gianni Luca // Journal of Neuro-Oncology;Jan2008, Vol. 86 Issue 1, p89 

    Abstract  Peripheral neuropathy (PN) is one of the most common and dose-limiting side effects of paclitaxel, a chemiotherapeutic drug of proven efficacy in various tumours. We investigated the pathophysiological features of the PN and the temporal relationships between the...

  • Diabetic Neuropathy: A Clinical and Neuropathological Study of 107 Patients. David S. Younger // Neurology Research International;2010, p1 

    One hundred seven patients were retrospectively studied from 1992 to 2002 with diabetic neuropathy that underwent peripheral nerve biopsy. Nerve biopsy revealed the underlying histopathology, including cell and humoral-mediated immunological lesions in the majority of patients. When combined...

  • Interferon-α-2a/ interferon-α-2b.  // Reactions Weekly;6/11/2005, Issue 1055, p12 

    Discusses research being done on case involving an elderly patient that developed multifocal leucoencephalopathy and polyneuropathy during long-term treatment with interferon-´ for hairy cell leukemia. Reference to a study by O. Sommer et al published in the February 2005 issue of "Leukemia...

  • Aplicaciones clínicas del ácido tióctico (ácido α-lipoico) en pacientes con neuropatía diabética sintomática: revisión. Brito, Carlos Cantú; Carvallo, Fidel Baizabal; Velasco, Jorge Aldrete; Güitrón, Eduardo Chavez // Medicina Interna de Mexico;mar/abr2007, Vol. 23 Issue 2, p151 

    Diabetes mellitus is the main cause of neuropathy worldwide, being common place for patients to suffer from it at some stage of the disease. Tioctic acid o α-lipoic acid and its related metabolites, due to their antioxidant and chelating properties, have proved an effective therapy for...

  • Cesium chloride.  // Reactions Weekly;8/22/2009, Issue 1266, p13 

    The article describes the case of a 65-year-old woman who developed torsade de pointes after taking a nonradioactive cesium chloride-containing alternative medicine for metastatic rectal cancer. The patient presented with recurrent syncope attacks of one day's duration six weeks after she...

  • A case of recurrent malignant fibrous histiocytoma with marked response to combined chemotherapy with gemcitabine and carboplatin. Zhang Wei; Luan Li; Xiao-Yu Xu; Hong Wang; Aman Wang; Hai-Bo Zhu; Qian Zhang; Ling Wang // Archives of Medical Science;Oct2014, Vol. 10 Issue 5, p1057 

    The article presents a case study of a 60-year-old man who was taken to Beijing Ji Shuitan Hospital due to recurrent tumor on the stump of the right lower limb and severe pain. He was examined under excisional biopsy and determined a malignant fibrous histiocytoma (MFH). He underwent...

  • TWEAK Appears as a Modulator of Endometrial IL-18 Related Cytotoxic Activity of Uterine Natural Killers. Petitbarat, Marie; Rahmati, Mona; Sérazin, Valérie; Dubanchet, Sylvie; Morvan, Corinne; Wainer, Robert; de Mazancourt, Philippe; Chaouat, Gérard; Foidart, Jean-Michel; Munaut, Carine; Lédée, Nathalie // PLoS ONE;2011, Vol. 6 Issue 1, p1 

    Background: TWEAK (Tumor necrosis factor like WEAK inducer of apoptosis) is highly expressed by different immune cells and triggers multiple cellular responses, including control of angiogenesis. Our objective was to investigate its role in the human endometrium during the implantation window,...


Read the Article


Sign out of this library

Other Topics