Reversal of DNA hypomethylation by Folic acid supplements: possible role in cancer prevention

Mathers, J C
May 2005
Gut;May2005, Vol. 54 Issue 5, p579
Academic Journal
The article focuses on the role of reversal of DNA hypomethylation by folic acid supplements in prevention of colorectal cancer. The deranged gene expression that is causal for colorectal cancer (CRC) development results from unrepaired genomic damage which accumulates in successive generations of mucosal cells and which provides the neoplasm with a growth and/or survival advantage. Diet, lifestyle, and other non-genetic factors have a strong influence on CRC risk, with obesity and possibly red or processed meat increasing the risk while higher intakes of plant foods may be protective.


Related Articles

  • Folic acid protects the colon.  // Consumer Reports on Health;Dec98, Vol. 10 Issue 12, p5 

    Highlights the results of the Nurses' Health Study which shows evidence that the B vitamin folic acid may help prevent colon cancer.

  • Reducing risk of colon cancer...  // FDA Consumer;Jan/Feb99, Vol. 33 Issue 1, p4 

    Reports on the findings of a study by Brigham and Women's Hospital in Boston, Massachusetts on the significance of multivitamins on women's risk of colon cancer. Findings about folic acid; Amount of folic acid needed.

  • Folate: a magic bullet or a double edged sword for colorectal cancer prevention? Kim, Y.-I. // Gut;Oct2006, Vol. 55 Issue 10, p1387 

    The article focuses on the relationship between folate depletion and colorectal cancer risk. The author states that low folate status may suppress colorectal carcinogenesis and high folate status may promote colorectal carcinogenesis. According to the author, animal studies and intervention...

  • Folic acid keeps cancer at bay.  // Health (Time Inc. Health);Jan/Feb99, Vol. 13 Issue 1, p13 

    Presents the result of a study conducted by Harvard researchers which suggests that folic acid can ward off colon cancer in women. How Harvard researchers tracked down the colon cancer incidence among women; Sources of folic acid; Daily dosage of folic acid needed to stave off 30 to 40 percent...

  • Fiber Survives a Roughing-Up. Aschwanden, Christie; Baker, Mitzi; Guterman, Lila; Jegelian, Karin; Waters, Rob; Yang, Sarah // Health (Time Inc. Health);Apr99, Vol. 13 Issue 3, p15 

    Focuses on the benefits of eating fiber-rich food. Findings of a study conducted by Charles Fuchs and colleagues in Harvard University about women who consumed fiber; Sources of folic acid; Other ways to prevent colon cancer.

  • Multivitamins greatly reduce colon cancer risk. Pinkowish, Mary Desmond // Patient Care;12/15/1998, Vol. 32 Issue 20, p27 

    Reports on a study on the use of folate supplementation to prevent colon cancer in the United States. Reduction in colon cancer risk in patients taking folate-containing multivitamins; Daily intake of folate; Effects of folate on advanced tumors.

  • Protect Your Colon. Williams, Stephen // Newsweek;10/19/1998, Vol. 132 Issue 16, p88 

    Notes a report in `Annals of Internal Medicine' suggesting a link between dietary intake of folic acid from multivitamins and reduced risk of colon cancer. Size of the study; Details of the findings.

  • Fight Cancer "Down There". McCord, Holly; McVeigh, Gloria // Prevention;Apr2003, Vol. 55 Issue 4, p61 

    Getting the highest amount of folate from foods slashed colon cancer risk in men and women and rectal cancer in men by 30%, according to a 7-year study of more than 120,000 people (Cancer, Oct 2002). The colon and rectum are the third most common sites for new tumors, and these cancers rank...

  • Colon vitamins. Fischman, Josh // U.S. News & World Report;3/25/2002, Vol. 132 Issue 9, p49 

    Reports that a diet high in vitamins--particularly folic acid--high in the amino acid methionine, and low in alcohol can reduce the family-related risk of colon cancer. Mention of the report published in 'Cancer Epidemiology, Biomarkers & Preventions'; Possible complications involved with...


Read the Article


Sign out of this library

Other Topics