Reversal of DNA hypomethylation by Folic acid supplements: possible role in cancer prevention

Mathers, J C
May 2005
Gut;May2005, Vol. 54 Issue 5, p579
Academic Journal
The article focuses on the role of reversal of DNA hypomethylation by folic acid supplements in prevention of colorectal cancer. The deranged gene expression that is causal for colorectal cancer (CRC) development results from unrepaired genomic damage which accumulates in successive generations of mucosal cells and which provides the neoplasm with a growth and/or survival advantage. Diet, lifestyle, and other non-genetic factors have a strong influence on CRC risk, with obesity and possibly red or processed meat increasing the risk while higher intakes of plant foods may be protective.


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