TITLE

A kinetic model and its parameter estimation for the process of binding copper to human serum albumin by a voltammetric method

AUTHOR(S)
Kejun Zhong; Jianjun Xia; Wanzhi Wei; Yanbo Hu; Han Tao; Wei Liu
PUB. DATE
April 2005
SOURCE
Analytical & Bioanalytical Chemistry;Apr2005, Vol. 381 Issue 8, p1552
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Linear sweep anodic stripping voltammetry was applied to determine the concentration of free copper ions in the process of binding copper to human serum albumin (HSA) on the mercaptoethane sulfonate modified gold electrode surface. A kinetic model of two consecutive steps for the process of binding copper to HSA was first proposed on the basis of the electrochemical results and compared with a parallel kinetic response model by using residual analysis. The experimental data of the stripping peak currents with time was fitted according to the model and the kinetic parameters, binding rate constants,k1 andk2, were estimated to be 0.411 and 0.055 min-1, respectively.
ACCESSION #
16865351

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics