TITLE

The Effect Of Hyaluronic Acid On Vascular Surgical Adhesions

AUTHOR(S)
Canbaz, Suat
PUB. DATE
January 2004
SOURCE
Internet Journal of Thoracic & Cardiovascular Surgery;2004, Vol. 7 Issue 1, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Hyaluronic acid solutions and membranes have been shown experimentally to reduce adhesions following several surgical procedures. We purposed to investigate the efficacy of a bioresorbable membrane containing hyaluronic acid in preventing experimental vascular adhesions. Methods: The abdominal aortas of twelve adult rabbits were explored, cleared from surrounding tissues and abraded following median laparotomy. In six animals, bioresorbable membrane (Seprafilm(r)) was wrapped around the abdominal aorta; no similar procedure was performed in the remaining six (control) animals. Two months later, the abdominal aortas were re-explored and periaortic adhesions were scored. Results: Some clinically significant periaortic adhesions were observed at re-exploration in all the animals. The mean adhesion scores of the periaortic tissues were 2.83 ± 0.75 in animals treated with bioresorbable membrane and 3.16 ± 0.75 in the controls. The difference between the groups was not statistically significant (p>0.05). Conclusion: The bioresorbable membrane did not significantly reduce the formation of adhesions after aortic vascular surgery. The use of hyaluronic acid for preventing adhesions was not effective, except for serosal membranes.
ACCESSION #
16857605

 

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