The Effect Of Hyaluronic Acid On Vascular Surgical Adhesions

Canbaz, Suat
January 2004
Internet Journal of Thoracic & Cardiovascular Surgery;2004, Vol. 7 Issue 1, p1
Academic Journal
Objective: Hyaluronic acid solutions and membranes have been shown experimentally to reduce adhesions following several surgical procedures. We purposed to investigate the efficacy of a bioresorbable membrane containing hyaluronic acid in preventing experimental vascular adhesions. Methods: The abdominal aortas of twelve adult rabbits were explored, cleared from surrounding tissues and abraded following median laparotomy. In six animals, bioresorbable membrane (Seprafilm(r)) was wrapped around the abdominal aorta; no similar procedure was performed in the remaining six (control) animals. Two months later, the abdominal aortas were re-explored and periaortic adhesions were scored. Results: Some clinically significant periaortic adhesions were observed at re-exploration in all the animals. The mean adhesion scores of the periaortic tissues were 2.83 ± 0.75 in animals treated with bioresorbable membrane and 3.16 ± 0.75 in the controls. The difference between the groups was not statistically significant (p>0.05). Conclusion: The bioresorbable membrane did not significantly reduce the formation of adhesions after aortic vascular surgery. The use of hyaluronic acid for preventing adhesions was not effective, except for serosal membranes.


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