Anti-inflammatory gene therapy in the donor improves graft function after lung transplantation

Fisher, A.
April 2005
Thorax;Apr2005, Vol. 60 Issue 4, p319
Academic Journal
The article presents a study, which shows that anti-inflammatory gene therapy can be delivered to the airway in an animal model and can subsequently successfully disrupt the pro-inflammatory cascade in the lung. The implications of this work extend beyond the protection of early graft function after lung transplantation to include other clinical scenarios associated with acute lung injury. Ischaemia-reperfusion injury remains an important cause of primary graft failure and early mortality after lung transplantation. Interleukin (IL)-1, an early response and potent pro-inflammatory cytokine, has been implicated in the pathophysiology. In this paper the role of transfection of donor lungs with an adenoviral vector for soluble type I IL-1 receptor, an inhibitor of IL-1 activity, was investigated.


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