Evidence for a genetic susceptibility to lung carcinoma

Carlin, C.
April 2005
Thorax;Apr2005, Vol. 60 Issue 4, p287
Academic Journal
The article presents an evidence for a genetic susceptibility to lung carcinoma. Previous studies of the genetic epidemiology of lung cancer have suggested a modest (two-fold) increased risk associated with a family history of lung cancer. It has been unclear whether the increased risk observed reflected genetic factors specific to lung cancer, genetic modifiers of nicotine addiction (leading to increased tobacco exposure), or shared environmental factors. An increased relative risk of lung cancer was also seen in the second and third degree relatives of pro-bands, again in excess of the relative risk of smoking. Spouses of patients had a slightly increased risk of developing lung cancer but this appears to relate to a common environment; their relative risk of smoking exceeded that of lung cancer.


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