TITLE

Absence of C/EBPα may cause bronchial smooth muscle proliferation in asthma

AUTHOR(S)
Rahman, N. M.
PUB. DATE
April 2005
SOURCE
Thorax;Apr2005, Vol. 60 Issue 4, p281
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article states that proliferation of bronchial smooth muscle (BSM) cells occurs in the airways of asthmatic patients. Glucocorticoid s exerts antiproliferative effects via C CAAT/enhancer binding protein (C/EBPcz), an antiproliferative transcription factor. This paper studies signalling pathways in BSM cell proliferation from. 20 asthmatic and 26 non-asthmatic subjects (lung cancer/CF/emphysema). A series of elegant experiments (using immunoblotting/electrophoresis) first established that, in response to glucocorticoid, asthmatic and non-asthmatic BSM cells display similar glucocorticoid receptor (GR) characteristics, similar anti-inflammatory effects (interleukin (IL)-6 suppression), and a similar reduction in IL-6 suppression with a GR inhibitol.
ACCESSION #
16843150

 

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