TITLE

Appropriate Surgical Management of Small Hepatocellular Carcinomas in Patients Infected with Hepatitis C Virus World J. Surg. Vol 27, No 4, April 2003

AUTHOR(S)
Kubo, Shoji; Taukamoto, Tadashi; Hirohashi, Kazuhiro; Tanaka, Hiromu; Shuto, Taichi; Takemura, Shigekazu; Kawai, Shuichi; Wakasa, Kenichi; Kinoshita, Hiroaki
PUB. DATE
April 2003
SOURCE
World Journal of Surgery;Apr2003, Vol. 27 Issue 4, p437
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We investigated the incidence of recurrence after resection of small hepatocellular carcinomas (HCC) in patients infected with hepatitis C virus (HCV) to determine the appropriate surgical management of these patients. Sixty-one patients with anti-HCV antibody who underwent curative liver resection for small HCC (≦ 2.0 cm in greatest diameter) were categorized into two groups. Group 1 consisted of 27 patients with serum concentrations of type IV collagen 7S domain (7S collagen), a marker for hepatic fibrosis, < 8 ng/ml. Group 2 consisted of 34 patients with serum concentrations of 7S collagen ≧ 8 ng/ml. Serum concentration of 7S collagen correlated with the severity of active hepatitis and the degree of fibrosis in the noncancerous hepatic tissue, both of which are related to risk potential of hepatocarcinogenesis. Serum concentration of total bilirubin, aspartate aminotransferase activity, indocyanine green retention rate at 15 minutes, the proportion of patients who were Child-Pugh class B, and the proportion of patients with severe active hepatitis or cirrhosis (determined by histologic examination) were significantly higher in group 2 than in group 1. Platelet count was significantly lower in group 2. Tumor-free survival rates were not different between the groups. In group 1, nonanatomic resection was a risk factor for recurrence by univariate and multivariate analyses (odds ratio = 3.45, p = 0.040). In group 2, nonanatomic resection was not a risk factor for recurrence. In patients with small HCV-related HCC, anatomic resection is recommended when the serum concentration of 7S collagen is low (< 8 ng/ml) because the potential of hepatocarcinogenesis may be low even after the operation.
ACCESSION #
16820808

 

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