TITLE

Prediction of Malignant Potential in Reflux Disease: Are Cytokine Polymorphisms Important?

AUTHOR(S)
Gough, Martin D.; Ackroyd, Roger; Majeed, Ali W.; Bird, Nigel C.
PUB. DATE
May 2005
SOURCE
American Journal of Gastroenterology;May2005, Vol. 100 Issue 5, p1012
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES: Esophageal reflux is common in the Western world and can lead to a number of diseases, such as esophagitis, Barrett's esophagus, and adenocarcinoma. Barrett's predisposes to adenocarcinoma and endoscopic surveillance may lead to earlier detection of adenocarcinoma. However, clinical methods only identify one patient in 15 with Barrett's esophagus. The aim of this study was to find factors that may help identify patients with Barrett's earlier.METHODS: Blood samples and detailed histories were taken from 456 patients with gastroesophageal reflux who were recruited into three study groups: esophagitis, Barrett's esophagus without dysplasia, and Barrett's with dysplasia or adenocarcinoma. PCR was used to determine the frequency of five functional cytokine polymorphisms: interleukin-1 receptor antagonist position+2018 (IL-1 Ra+2018), interleukin-1β position−511 (IL-1β−511), tumor necrosis factor-α position−238 (TNF-α−238), interleukin-10 position+1082 (IL-10+1082), and interleukin-4 receptor position−1902 (IL-4R−1902).RESULTS: IL-1 Ra+2018 genotype 2/2 was associated with Barrett's more commonly than esophagitis (OR-3.7,p= 0.0345). The IL-10+1082 genotype 2/2 was more strongly associated with Barrett's and adenocarcinoma than esophagitis (OR-1.76,p= 0.056 and OR 1.96,p= 0.025, respectively). There were no differences for the IL-1β−511, IL-4R−1902, and TNF-α−238 polymorphisms.CONCLUSIONS: Cytokine polymorphisms are more commonly found in patients with Barrett's or adenocarcinoma than those with esophagitis. Together with demographic data, this may help identify those patients with Barrett's who would benefit from surveillance.(Am J Gastroenterol 2005;100:1012–1018)
ACCESSION #
16783593

 

Related Articles

  • Gastroesophageal Reflux Disease - An Update. Mushtaque, A. R. // Bangladesh Journal of Medical Science;Jan2010, Vol. 9 Issue 1, p14 

    Gastroesophageal reflux disease (GERD) is a common disease and a considerable burden on healthcare resources. Definitions and terminology have been a source of confusion for GERD. The 'Montreal definition' is the first ever global consensus definition of GERD. The esophageal and extraesophageal...

  • Association between interleukin-1β-511C/T polymorphism and reflux esophagitis in Japan. Muramatsu, Atsushi; Azuma, Takeshi; Okuda, Tomoyuki; Satomi, Satoko; Ohtani, Masahiro; Lee, Soshoku; Suto, Hiroyuki; Ito, Yoshiyuki; Yamazaki, Yukinao; Masaru Kuriyama // Journal of Gastroenterology;Sep2005, Vol. 40 Issue 9, p873 

    Background. Interleukin-1β (IL-1β) gene polymorphisms are related to hypochlorhydria and increase the risk of gastric cancer in the presence of Helicobacter pylon infection. However, little information is available about the genetic risk factors of reflux esophagitis. In this study we...

  • Endoscopy for Barrett's Esophagus and Esophageal Adenocarcinoma. Shaheen, Nicholas // American Family Physician;5/1/2004, Vol. 69 Issue 9, p2060 

    Focuses on the endoscopic screening for Barrett's esophagus and esophageal adenocarcinoma in patients with reflux symptoms. Relation of gastroesophageal reflux disease with cancer; Benefits from medical screening tests; Prevalence of Barrett's esophagus in the U.S.

  • Screening for Barrett's Esophagus. DeVault, Kenneth R. // American Family Physician;5/1/2004, Vol. 69 Issue 9, p2061 

    Focuses on the endoscopic screening of Barrett's esophagus. Association between esophageal adenocarcinoma and gastroesophageal reflux disease; Biopsy of esophageal mucosa required for the diagnosis of Barrett's esophagus; Health risk of the routine biopsy of a squamocolumnar junction.

  • Upper endoscopy as a screening and surveillance tool in esophageal adenocarcinoma: a review of the evidence. Shaheen, Nicholas J.; Provenzale, Dawn; Sandler, Robert S. // American Journal of Gastroenterology;Jun2002, Vol. 97 Issue 6, p1319 

    Esophageal adenocarcinoma is a rare cancer that is increasing rapidly in incidence. Because gastroesophageal reflux disease (GERD) is a risk factor for the development of this cancer, endoscopic screening of individuals with GERD symptoms and endoscopic surveillance of those who are found to...

  • Prevalence and Predictors of Columnar Lined Esophagus in Gastroesophageal Reflux Disease (GERD) Patients undergoing upper endoscopy. Balasubramanian, Gokulakrishnan; Singh, Mandeep; Gupta, Neil; Gaddam, Srinivas; Giacchino, Maria; Wani, Sachin B; Moloney, Brian; Higbee, April D; Rastogi, Amit; Bansal, Ajay; Sharma, Prateek // American Journal of Gastroenterology;Nov2012, Vol. 107 Issue 11, p1655 

    OBJECTIVES:Chronic gastroesophageal reflux disease (GERD) is a risk factor for Barrett's esophagus (BE), the most important surrogate marker for the development of esophageal adenocarcinoma (EAC). The need to document the presence of intestinal metaplasia in esophageal biopsies from a columnar...

  • Heartburn → Adenocarcinoma of Esophagus. Young, R. L.; Thompson, Jon S. // American Journal of Gastroenterology;Aug1999, Vol. 94 Issue 8, p2007 

    Provides information on a Swedish study which evaluated the association of gastroesophageal reflux and esophageal adenocarcinoma. Patients that were interviewed in the study; Persons with the highest odds ratio for developing esophageal adenocarcinoma; Need for on-going re-examination of the...

  • Manometric findings in patients with isolated distal gastroesophageal reflux. Ozin, Yasemin; Dagli, Ulku; Kuran, Sedef; Sahin, Burhan; Fisichella, Marco // World Journal of Gastroenterology;11/21/2009, Vol. 15 Issue 43, p5461 

    AIM: To analyze manometric abnormalities in patients with isolated distal reflux and compare these findings in patients with erosive and non-erosive disease. METHODS: Five hundred and fifty patients who presented to the outpatient clinic of Turkiye Yuksek Ihtisas Hospital with gastroesophageal...

  • The Impact of Open Access 24-h pH-Metry on the Diagnosis and Management of Esophageal Reflux Disease. Eckardt, V. F.; Dilling, B.; Bernhard, G. // American Journal of Gastroenterology;Mar1999, Vol. 94 Issue 3, p616 

    OBJECTIVE: This study investigates whether the results of 24-h pH-metry can be predicted from clinical information and whether they affect patient management. METHODS: A total of 200 consecutive patients referred for 24-h pH-metry underwent structured interviews as well as endoscopic and...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics