TITLE

Streptokinase and Heparin in the Treatment of Pulmonary Embolism: A Randomized Comparison

AUTHOR(S)
Dotter, Charles T.; Seaman, Arthur J.; Rösch, Josef; Porter, John M.
PUB. DATE
January 1979
SOURCE
Vascular Surgery;Jan/Feb1979, Vol. 13 Issue 1, p42
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Treatment with streptokinase followed by heparin was compared on a randomized basis with treatment with heparin alone in patients with acute pulmonary embolism. The diagnosis and results of treatment were established by pulmonary angiography. Fifteen patients received streptokinase and 16 received heparin alone. Complications included bleeding and pyrexia in both treatment groups and anaphylaxis in a patient receiving streptokinase. There were three deaths attributed to the disease its treatment. Patients in the streptokinase group had significantly greater angiographic improvement (P = 0.0125) than those in the heparin group.
ACCESSION #
16757698

 

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