Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training

Nicklas, Barbara J.; You, Tongjian; Pahor, Marco
April 2005
CMAJ: Canadian Medical Association Journal;4/26/2005, Vol. 172 Issue 9, p1199
Academic Journal
journal article
Persistent low-grade inflammation, as indicated by higher circulating levels of inflammatory mediators such as C-reactive protein, interleukin-6 and tumour necrosis factor-alpha, is a strong risk factor for several chronic diseases. There are data indicating that decreasing energy intake and increasing physical activity may be effective therapies for reducing overall inflammation. Evidence is strong that circulating levels of inflammatory markers are elevated with total and abdominal obesity, possibly owing to a higher secretion rate of cytokines by adipose tissue in obese people. Moreover, very-low-energy dietary weight loss reduces both circulating markers of inflammation and adipose-tissue cytokine production. Data from several large population-based cohorts show an inverse association between markers of systemic inflammation and physical activity or fitness status; small-scale intervention studies support that exercise training diminishes inflammation. Dietary weight loss plus exercise is likely more effective than weight reduction alone in reducing inflammation. To date, data from randomized, controlled trails designed to definitively test the effects of weight loss or exercise training, or both, on inflammation are limited. Future studies are required to define the amount of weight loss needed for clinically meaningful reductions of inflammation; in addition, fully powered and controlled studies are necessary to clarify the effect of exercise training on chronic, systemic inflammation.


Related Articles

  • Protecting against the lethal effects of chronic inflamation.  // Life Extension;May2003, Vol. 9 Issue 5, p18 

    Discusses the protection against the lethal effects of chronic inflammation. Characteristics of people suffering from chronic disease; Cytokine panel and optimal anti-inflammatory ranges; Importance of cytokine testing for those suffering from chronic illness; Methods of lowering elevated...

  • Exercise as a Mean to Control Low-Grade Systemic Inflammation. Mathur, Neha; Pedersen, Bente Klarlund // Mediators of Inflammation;2008, Vol. 2008 Issue 2, Special section p1 

    Chronic noncommunicable diseases (CNCDs), which include cardiovascular disease, some cancers, for example, colon cancer, breast cancer, and type 2 diabetes, are reaching epidemic proportions worldwide. It has now become clear that low-grade chronic inflammation is a key player in the...

  • Weight Loss and its Role in Reducing Chronic Inflammation. Sauter, Edward R. // AMAA Journal;Winter2013, Vol. 26 Issue 1, p8 

    The article focuses on the importance of weight loss in the reduction of chronic inflammation. The chance of developing chronic inflammation among obese individuals can be lessened by decreasing the inflammatory stimulus by losing weight through surgical intervention, diet or diet and exercise....

  • Efficacy of a meal replacement diet plan compared to a food-based diet plan after a period of weight loss and weight maintenance: a randomized controlled trial. Davis, Lisa M.; Coleman, Christopher; Kiel, Jessica; Rampolla, Joni; Hutchisen, Tammy; Ford, Laura; Andersen, Wayne S.; Hanlon-Mitola, Andrea // Nutrition Journal;2010, Vol. 9, p11 

    Background: Obesity has reached epidemic proportions in the United States. It is implicated in the development of a variety of chronic disease states and is associated with increased levels of inflammation and oxidative stress. The objective of this study is to examine the effect of Medifast's...

  • 30-DAY WALKING PLANNER.  // Prevention;Jul2003, Vol. 55 Issue 7, p144 

    Presents a 30-day walking planner for physical fitness. Health benefits of walking, including the prevention of chronic disease and control of one's weight.

  • Chronic Inflammation: Role of Adipose Tissue and Modulation by Weight Loss. Tongjian You; Nicklas, Barbara J. // Current Diabetes Reviews;2006, Vol. 2 Issue 1, p29 

    Chronic inflammation has been linked with an increased risk of type 2 diabetes and cardiovascular disease. As an endocrine and inflammatory organ, adipose tissue is an important source of circulating pro-inflammatory cytokines. Current evidence strongly supports that chronic inflammation is...

  • Make Small Changes for Better Health.  // Chicago Citizen - Chatham Southeast Edition;5/16/2012, Vol. 47 Issue 8, p12 

    The article presents information on the tips by the National Diabetes Education Program of the U.S. for reducing the risk of chronic diseases, type 2 diabetes and living a healthy lifestyle that includes the setting up of goals for reducing weight.

  • FIGHTING INFLAMMATION. Lim, Dennis // Nutrition Action Health Letter;Nov2011, Vol. 38 Issue 9, p9 

    The article focuses on how to reduce a person's inflammatory factors. Some of the illnesses that have been linked to chronic inflammation include heart disease, cancer and Alzheimer's disease. It cites the role of inflammation in cancers of the lung, esophagus and cervix. It details the ways in...

  • Exercise Can Benefit People with Asthma.  // Women's Health Advisor;Feb2014, Vol. 18 Issue 2, p5 

    The article focuses on the benefits of exercise in asthmatic patients. According to a study published in "The Cochrane Library", a collection of six databases, asthma patients tolerated physical exercises and showed improvement in maximum oxygen uptake. Topics discussed include views of doctor...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics