Quantitative determination of cationic modified polysaccharides on hair using LC-MS and LC-MS-MS

Ungewiß, Jan; Vietzke, Jens-Peter; Rapp, Claudius; Schmidt-Lewerkühne, Hartmut; Wittern, Klaus-Peter; Salzer, Reiner
April 2005
Analytical & Bioanalytical Chemistry;Apr2005, Vol. 381 Issue 7, p1401
Academic Journal
Cationic polysaccharides containingN-hydroxypropyl-N,N,N-trimethylammonium substituents are widely used as conditioning agents for hair-care products. A sensitive method has been developed for the quantitation of these polymers. After acidic extraction from hair the polysaccharides are hydrolyzed using trifluoroacetic acid. The cationic monoglycosides are determined using liquid chromatography-tandem mass spectrometry (LC-MS-MS). The developed method is independent of hair treatment. Even hair cut from test persons after customary hair wash can be analyzed. After treatment of natural and bleached hair tresses using a real-life treatment procedure 180 µg and 300 µg of polymer per gram hair were quantified, respectively. Additionally the fragmentation mechanism of the cationicN-hydroxypropyl-N,N,N-trimethylammonium group during electrospray ionization was investigated. A mass loss of 60 Da in combination with loss of a single charge is observed and associated with cleavage of trimethylamine and a proton. It is assumed that this process is promoted by the anionic counter-ion which might be hydroxide in an aqueous environment.


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