TITLE

Protein Folding, Misfolding and Aggregation: Evolving Concepts and Conformational Diseases

AUTHOR(S)
Ramos, Carlos H. I.; Ferreira, S�rgio T.
PUB. DATE
April 2005
SOURCE
Protein & Peptide Letters;Apr2005, Vol. 12 Issue 3, p213
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Proteins carry out many vital cellular functions determined by their precise 3-dimensional structures (the native conformations). Understanding how proteins fold has long been a major goal and can be of great therapeutic value. Failure to reach or maintain the correct folded structure can have serious consequences, as in the conformational diseases. The ultimate goal of folding studies is to predict structure from sequence, allowing the design of new functional proteins and prevention of aberrant disease-associated conformations.
ACCESSION #
16677563

 

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