Lactic acidosis

De Backer, Daniel
May 2003
Intensive Care Medicine;May2003, Vol. 29 Issue 5, p699
Academic Journal
journal article
The article discusses about lactic acidosis. Lactate is a byproduct of glycolysis. In the energy producing metabolism of glucose two distinct processes occur. The first series of enzymatic reactions (Enden- Mierhoff pathway), occurring in the cytoplasm of cells, anaerobically transforms 1 molecule of glucose into 2 molecules of pyruvate, generating 2 molecules of ATP. Measurement has long involved sampling blood on iced fluoride tubes to inhibit in vitro red blood cells lactate production. Lactate is then measured on plasma using enzymatic colorimetry with lactate dehydrogenase.


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