TITLE

Hemodynamic Effects of Nebivolol in Men: Comparison of Radionuclide Angiocardiography with Systolic Time Intervals

AUTHOR(S)
Franken, Philippe; Vandevivere, Johan; Geukenst, Hedwig; Verhaegen, Herman
PUB. DATE
June 1988
SOURCE
Angiology;Jun1988, Vol. 39 Issue 6, p526
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In a subacute experiment the authors studied the effects of a fourteen-day treatment with nebivolol, 5 mg once a day, in 10 healthy male volunteers with a mean age of thirty-one, twenty-five to thirty-nine years, by comparing the results of the resting ratio of the preejection period (PEP,) to the left ventricular ejection time (LVETJ, as measured by systolic time intervals (STI), with the results obtained by equilibrium radionuclide angiocardiography (ERNA), using technetium 99m-labeled autologous red blood cells as a marker. A submaximal treadmill exercise test performed before and during treatment demonstrated that nebivolol significantly (p≤0.01) reduced peak exercise heart rate and systolic blood pressure from a mean value of 158 ± 5.4 bpm to 131 ± 4.3 bpm and from 171 ± 4.9 mmHg to 144 ± 4.5 mmHg respectively. The data from the STI and ERNA were calculated and analyzed independently by two observers. A highly significant (r = 0.8182, p = 0.0038) correlation was found between the changes of stroke volume (SV) and PEP,/LVET, during treatment with nebivolol. Furthermore end-diastolic volume significantly (p = 0.03) increased from a mean value of 177 ± 10.1 ml to 198 ± 6 ml and stroke volume significantly (p=0.01) increased from 120 ± 6.8 ml to 136 ± 6.3 ml. Systemic vascular resistance tended to decrease from a mean value of 11.4 ± 1.28 units to 10.6 ± 1.10 units. No changes could be observed either in ejection fraction or in cardiac output. The ratio of the PEPc/LVETc, as measured with STI, significantly (p = 0.03) improved from a mean value of 0.34 ± 0.011 to 0.30 ± 0.010, and these changes were due to both a decrease of PEPc and an increase of LVETc. The postexercise LVETc which is a marker of the positive inotropy of the exercise, significantly (p=0.002) shortened with 49 ± 4.6 msec in control conditions and also during treatment with nebivolol with 30 ± 4.6 msec (p=0.002). From all these data it appears that nebivolol, unlike classical beta-blockers, beneficially influences cardiac function at rest, owing to a combined effect on both preload and afterload. These ancillary hemodynamic activities of nebivolol may be useful in the treatment of elderly hypertensive patients with left ventricular damage.
ACCESSION #
16615545

 

Related Articles

  • Effects of landiolol, a short-acting beta-1 blocker, on hemodynamic variables during emergence from anesthesia and tracheal extubation in elderly patients with and without hypertension. MIYAZAKI, MASUMI; KADOI, YUJI; SAITO, SHIGERU // Journal of Anesthesia;2009, Vol. 23 Issue 4, p483 

    Tracheal extubation and emergence procedures induce abrupt changes in hemodynamics and humoral responses. We conducted a prospective randomized study to examine the effects of the short-acting beta-1 blocker, landiolol, on hemodynamics during emergence from anesthesia in elderly patients with...

  • One-Year Renal and Cardiac Effects of Bisoprolol versus Losartan in Recently Diagnosed Hypertensive Patients. Parrinello, Gaspare; Paterna, Salvatore; Torres, Daniele; Di Pasquale, Pietro; Mezzero, Manuela; La Rocca, Gabriella; Cardillo, Mauro; Trapanese, Caterina; Caradonna, Mario; Licata, Giuseppe // Clinical Drug Investigation;2009, Vol. 29 Issue 9, p591 

    Background and objectives: Hypertension is a significant cause of chronic renal injury and its effective treatment is capable of reducing the rate of renal failure. β-Adrenoceptor antagonists (β-blockers) have been reported to induce a deterioration in renal function, while several data...

  • Beta-blocker use in elderly patients with coronary heart disease. Kelly, James; Kelleher, Kevin // Age & Ageing;Jan2000, Vol. 29 Issue 1, p17 

    Presents information on a study which examined the evidence that beta-blockers are effective treatment in elderly patients with coronary heart disease. Evidence of beta-blockers' under-use in elderly patients with myocardial infarction; Tolerability of the blockers in elderly patients; Conclusions.

  • Cardiology.  // Caribbean Health;Feb2001, Vol. 4 Issue 1, p21 

    The article provides information on some research concerning cardiology. A study found that a simple risk score is helpful in assessing prognosis in patients with unstable angina/non-ST elevation myocardial infarction. A research showed that patients prescribed beta-blockers did better than...

  • THE PREVALENCE OF β-BLOCKER PRESCRIPTION IN COPD PATIENTS. Patel, A. R. C.; Donaldson, G. C.; Mackay, A. J.; Wedzicha, J. A.; Hurst, J. R. // Thorax;Dec2011 Supplement, pA175 

    Introduction Ischaemic heart disease (IHD) is a major cause of morbidity and mortality in COPD patients. Effective cardiovascular therapies may have significant impact in COPD populations. In particular, β-blockers have been shown to be safe and effective in COPD. We aimed to quantify the...

  • New molecular entity.  // Formulary;Feb2008, Vol. 43 Issue 2, p39 

    The article discusses the approval of Nebivolol, a beta-adrenergic receptor blocker for the treatment of hypertension. The approval was given on December 17, 2007 as a monotherapy or in combination with other antihypertensive agents. The drug's efficacy was assessed and determined to...

  • Review: lower dose combination antihypertensive therapy is preferable to standard dose single drug therapy. Linden, Wolfgang // Evidence Based Medicine;Jan/Feb2004, Vol. 9 Issue 1, p11 

    The article presents a study on the safety and efficacy of different doses and combinations of 5 main categories of blood pressure (BP) lowering drugs. The drugs that were studied were thiazides, beta blockers, ACE inhibitors, ARBs and calcium channel blockers. Researchers found that the 5 main...

  • Atenolol: Use with caution. Motylev, Alexander // Drug Topics;11/21/2005, Vol. 149 Issue 22, pHSE2 

    This article examines the effectiveness of selective beta 1-blocker atenolol for blood pressure control. Studies have reported that the selective beta 1-blocker atenolol, at doses of 50 to 100 milligrams, produced higher cardiovascular mortality and stroke risk rates compared with other...

  • TREATMENT OF HYPERTENSION.  // Monthly Prescribing Reference;Jan2011, Vol. 27 Issue 1, p8 

    The article focuses on the treatment of patients with hypertension. It notes that most patients will need to undergo two medications to reach the goal of having a blood pressure (BP) <140/90 mmHg or <130/80 mmHg in patients with diabetes or chronic kidney disease. It also discusses various...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics