Bevantolol vs Propranolol: A Double-Blind Controlled Trial in Essential Hypertension

Maclean, Derek
June 1988
Angiology;Jun1988, Vol. 39 Issue 6, p487
Academic Journal
Bevantolol is a novel β1-selective beta-adrenoceptor antagonist. The Study Group evaluated its therapeutic utility (100–300 mg bid) compared with propranolol (80–240 mg bid) in 266 patients with mild to moderate essential hypertension (WHO Grades I and II, sitting diastolic blood pressure (DBP) ≥ 95 mmHg). There was no difference in their antihypertensive efficacy over six months, 77% being controlled (DBP ≤ 90 mmHg) on bevantolol and 81% on propranolol. Hydrochlorothiazide 25–50 mg bid added later improved BP control in those incompletely controlled on bevantolol monotherapy. Both β-adrenoceptor antagonists also reduced intraocular pressure. Bevantolol caused significantly fewer adverse effects than propranolol with many fewer withdrawals during long-term therapy. This unique clinical pharmacologic profile of bevantolol enhances its therapeutic usefulness and may relate to alpha-adrenoceptor antagonist activity, as well as to its β1-selectivity.


Related Articles

  • Dangerous antihypertensive treatment.  // British Medical Journal;7/28/1979, Vol. 2 Issue 6184, p228 

    Discusses the effect of antihypertensive treatment on patients with hypertension in Great Britain. Inducement of symptoms on elderly patients treated for mild hypertension; Reduction of blood pressures in malignant hypertensive; Variations in arterial blood pressure throughout the normal daily...

  • TEKAMLO 150mg/5mg.  // Monthly Prescribing Reference;Oct2010, Vol. 26 Issue 10, pA.12 

    The article offers information on the antihypertensive drug Tekamlo from pharmaceutical company Novartis AG. It is indicated for the treatment of hypertension. The drug's pharmacology and adverse reactions which include diarrhea, cough, and rash, as well as its contraindications and dosage are...

  • Palpable effects of blood pressure tablets not all bad, say patients.  // Nursing Standard;4/26/2006, Vol. 20 Issue 33, p16 

    The article cites a study which explored patients' acceptance of the palpable side effects of antihypertensive drugs. Overall, some of the side effects were welcome, such as reduced blood pressure and increased calm. While some patients stopped taking the pills due to poor palpable effects, most...

  • Three-in-one pill for resistant BP.  // Clinical Advisor;Oct2010, Vol. 13 Issue 10, p23 

    The article offers information about the drug Tribenzor, an antihypertensive agent, from Diichi Sankyo. It notes that the drug is a combination of angiotensin 2 receptor blocker, dihydropyridine calcium, and thiazide diuretic. The drug is contraindicated to people with anuria and sulfonamide...

  • antihypertensive drugs. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p57 

    An encyclopedia entry for "antihypertensive drugs" is presented. They refer to a group of drugs used in the treatment of hypertension to prevent complications such as stroke, heart failure, myocardial infarction and kidney damage. These drugs, such as ACE inhibitors and angiotensin-II...

  • Efficacy and Tolerability of Different Antihypertensive Drugs in Patients with Mild to Moderate Hypertension in a Tertiary Care Hospital - A Prospective, Comparative Study. Yasmeen, Nazia; Varma, Ravindra K.; Siddiqua, Shahina S.; Donepudi, Aruna // Archives of Applied Science Research;2011, Vol. 3 Issue 1, p436 

    Aim: To compare efficacy and tolerability of different antihypertensive drugs in patients with essential hypertension. Materials and methods: An open label, prospective, comparative study was conducted in 252 patients suffering from mild to moderate hypertension of either sex aged between 30-80...

  • COMPARATIVE STUDY OF EFFECTS TWO β2 ADRENERGIC AGONISTS ON BIOCHEMICAL PARAMETERS IN MODERATE TO SEVERE BRONCHIAL ASTHMA PATIENTS. Rathore, Kavita; Sharma, Neha; Aseri, M. L.; Mathur, Sunil Kumar; Sankhla, Sanjay // International Journal of Pharmaceutical Sciences & Research;Jun2013, Vol. 4 Issue 6, p2419 

    Background: β2- agonist drugs are frequently prescribed in asthmatics. Apart from bronchodilation they affect biochemical and physical parameters of the body. Method: Total 80 patients were divided into two groups. Group I (n=40) received Albuterol- 2.5mg./2.5ml. TDS and Group II (n=40)...

  • Female preponderance for lisinopril-induced cough in hypertension. Smith, Jeanette M. // JAMA: Journal of the American Medical Association;2/22/95, Vol. 273 Issue 8, p600d 

    Presents the results of a study comparing the side effect of nifedipine and lisinopril treatment in women with hypertension. Report on the occurrence of coughing in both treatments.

  • Adverse effects of long-term use of beta agonists. Dale, David C.; Federman, Daniel D. // Cortlandt Forum;03/25/97, Vol. 10 Issue 3, p20 

    Reports that long-term administration of beta agonists may be associated with the development of tolerance and with increased airway responsiveness to allergen and to nonspecific stimuli. Recommendation for the use of inhaled steroids to counter the adverse effects of beta agonists.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics