TITLE

Reduced interferon-γ release in patients recovered from Legionnaires disease

AUTHOR(S)
Lettinga, K. D.; Weijer, S.; Speelman, P.; Prins, J. M.; van der Poll, T.; Verbon, A.
PUB. DATE
January 2003
SOURCE
Thorax;Jan2003, Vol. 58 Issue 1, p63
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Legionella pneumophila, a Gram negative intracellular pathogen, causes Legionnaires' disease (LD). Interferon (IFN)-γ is important for host defence against L pneumophila so reduced IFN-γ production capacity and/or responsiveness might render humans more susceptible to infection with L pneumophila. Methods: Seventy seven patients who suffered from LD after a point source outbreak one year earlier participated in the study. Whole blood was incubated with non-specific stimuli (lipopolysaccharide (LPS) or interleukin (IL)-12) or specific stimuli (viable or heat killed L pneumophila) to evaluate IFN-γ, production, and with IFN-γ to evaluate IFN-γ responsiveness. Expression of complement receptor 3 on monocytes was determined by flow cytometry. Thirty seven companions who were also exposed but had not developed LD served as controls. Results: Patients released less IFN-γ than controls in response to stimulation with LPS (mean (SE) 393 (58) pg/ml v 914 (178) pg/ml; p=0.001) and IL-12 (96 (14) pg/ml v 177 (41) pg/ml; p=0.058). IFN-γ responsiveness, measured by release of IFN-γ inducible protein (IP)-10, tumour necrosis factor α, IL-12 production capacity, and monocyte expression of complement receptor 3, did not differ between patients and controls. IFN-γ release after stimulation with LPS and IP-10 release after stimulation with IFN-γ were weakly associated with severity of LD in the former patient group (p=-0.3, p=0.011 and P=-0.3, p=0.037, respectively). Conclusion: These results suggest that impaired IFN-γ production may contribute to susceptibility to L pneumophila infection.
ACCESSION #
16589531

 

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