TITLE

High serum concentrations of surfactant protein A in usual interstitial pneumonia compared with non-specific interstitial pneumonia

AUTHOR(S)
Ishii, H.; Mukae, H.; Kadota, J.; Kaida, H.; Nagata, T.; Abe, K.; Matsukura, S.; Kohno, S.
PUB. DATE
January 2003
SOURCE
Thorax;Jan2003, Vol. 58 Issue 1, p52
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The pathological diagnosis of interstitial lung diseases (ILD) by surgical lung biopsy is important for clinical decision making. There is a need, however, to use serum markers for differentiating usual interstitial pneumonia (UIP) from other ILD. Surfactant protein (SP)-A, SP-D, KL-6, sialyl SSEA-1 (SLX), and sialyl Lewis° (CA19-9) are useful markers for the diagnosis and evaluation of activity of ILD. We have investigated the usefulness of these proteins as markers of UIP. Methods: Serum and bronchoalveolar lavage (BAL) fluid levels of the above five markers were measured in 57 patients with various forms of ILD (19 with UIP, 12 with non-specific interstitial pneumonia (NSIP), eight with bronchiolitis obliterans organising pneumonia (BOOP), and 10 with sarcoidosis), eight patients with the control disease (diffuse panbronchiolitis (DPB)), and nine healthy volunteers. Results: Serum levels of SPA, SP-D, and KL-6 in patients with UIP and NSIP were significantly higher than in healthy volunteers. In particular, the serum levels of SP-A in patients with UIP were significantly higher than in patients with NSIP (p<0.0001, mean difference -58.3 ng/ml, 95% confidence interval -81.6 to -35.0), and BAL fluid levels of SP-D in patients with UIP were significantly lower than in patients with NSIP (p=0.01, mean difference 322.4 ng/ml, 95% confidence interval 79.3 to 565.5). Conclusion: Serum SPA levels may be clinically useful as a biomarker to differentiate between UIP and NSIP.
ACCESSION #
16589528

 

Related Articles

  • Surfactant and lung inflammation. Reid, K. B. M.; Clark, H.; Palaniyar, N. // Thorax;Aug2005, Vol. 60 Issue 8, p620 

    Examines the role of surfactants for the treatment of lung inflammation. Ability of the surfactant system to reduce alveolar surface tension and thereby prevent collapse of the alveoli on expiration; Therapeutic use of exogenous surfactant; Structure of two important human surfactant proteins;...

  • Lung surfactant in subacute pulmonary disease. Devendra, Gehan; Spragg, Roger G. // Respiratory Research;2002, Vol. 3, p19 

    Pulmonary surfactant is a surface active material composed of both lipids and proteins that is produced by alveolar type II pneumocytes. Abnormalities of surfactant in the immature lung or in the acutely inflamed mature lung are well described. However, in a variety of subacute diseases of the...

  • Standardized lung recruitment during high frequency and conventional ventilation: similar pathophysiologic and inflammatory responses in an animal model of respiratory distress syndrome. Krishnan, Ramesh K. M.; Meyers, Pat A.; Worwa, Cathy; Goertz, Ronald; Schauer, Galen; Mammel, Mark C. // Intensive Care Medicine;Jun2004, Vol. 30 Issue 6, p1195 

    Objective: To evaluate standardized lung recruitment strategy during both high frequency oscillation (HFO) and volume-targeted conventional ventilation (CV+V) in spontaneously breathing piglets with surfactant washout on pathophysiologic and inflammatory responses.Design:...

  • Pulmonary Alveolar Proteinosis – Is Host Defense Awry? Doerschuk, Claire M. // New England Journal of Medicine;2/8/2007, Vol. 356 Issue 6, p547 

    The author offers observation on pulmonary alveolar proteinosis, a rare disorder that has an incidence rate of 0.36 per million. The disorder, which usually requires lung biopsy in order to be diagnosed, results from either decreased degradation of surfactant or surfactant dysfunction. Symptoms...

  • Interactions between LPS and lung surfactant proteins. Chaby, Richard; Garcia-Verdugo, Ignacio; Espinassous, Quentin; Augusto, Luis A. // Journal of Endotoxin Research;2005, Vol. 11 Issue 3, p181 

    After penetration into the lower airways, bacterial lipopolysaccharide (LPS) interacts with alveolar cells in a fluid environment consisting of pulmonary surfactant, a lipid�protein complex which prevents alveolar collapsing and participates in lung defense. The two hydrophilic surfactant...

  • Immunoregulatory functions of surfactant proteins. Wright, Jo Rae // Nature Reviews Immunology;Jan2005, Vol. 5 Issue 1, p58 

    Because the lungs function as the body's gas-exchange organ, they are inevitably exposed to air that is contaminated with pathogens, allergens and pollutants. Host-defence mechanisms within the lungs must facilitate clearance of inhaled pathogens and particles while minimizing an inflammatory...

  • Pulmonary surfactant-associated protein A and asthma. Yan Xing-ke; Yang Bo; Gao Yang // Journal of US-China Medical Science;Aug2007, Vol. 4 Issue 8, p35 

    This paper reviews the pulmonary surfactant-associated protein A (SP-A) and the relationship between asthma. Data indicate that SP-A is a pulmonary surfactant (PS) of major components, SP-A activity in the maintenance of the PS, small airway and alveolar stability, regulating specific immune...

  • The role of surfactant in asthma. Hohlfeld, Jens M. // Respiratory Research;2002, Vol. 3, p4 

    Pulmonary surfactant is a unique mixture of lipids and surfactant-specific proteins that covers the entire alveolar surface of the lungs. Surfactant is not restricted to the alveolar compartment; it also reaches terminal conducting airways and is present in upper airway secretions. While the...

  • Surfactant gene polymorphisms and interstitial lung diseases. Pantelidis, Panagiotis; Veeraraghavan, Srihari; Du Bois, Roland M. // Respiratory Research;2002, Vol. 3, p14 

    Pulmonary surfactant is a complex mixture of phospholipids and proteins, which is present in the alveolar lining fluid and is essential for normal lung function. Alterations in surfactant composition have been reported in several interstitial lung diseases (ILDs). Furthermore, a mutation in the...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics