Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study

Rohde, G.; Wiethege, A.; Borg, I.; Kauth, M.; Bauer, T. T.; Gillissen, A.; Bufe, A.; Schultze-Werninghaus, G.
January 2003
Thorax;Jan2003, Vol. 58 Issue 1, p37
Academic Journal
Background: Acute exacerbations of chronic obstructive pulmonary disease (AE-COPD) are a common cause of hospital admission. Many exacerbations are believed to be due to upper and/or lower respiratory tract viral infections, but the incidence of these infections in patients with COPD is still undetermined. Methods: Respiratory syncytial virus (RSV), influenza A and B, parainfluenza 3, and picornaviruses were detected by nested reverse transcription polymerase chain reaction (RT-PCR) in upper )nasal lavage) and lower respiratory tract specimens )induced sputum). In a 2:1 case-control set up, 85 hospitalised patients with AE-COPD and 42 patients with stable COPD admitted for other medical reasons were studied. Results: Respiratory viruses were found more often in sputum and nasal lavage of patients with AE-COPD (48/85, 56%) than in patients with stable COPD )8/42, 19%, p


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