TITLE

Changes in Renal Function Associated with Tenofovir Disoproxil Fumarate Treatment, Compared with Nucleoside Reverse-Transcriptase Inhibitor Treatment

AUTHOR(S)
Gallant, Joel E.; Parish, Michelle A.; Keruly, Jeanne C.; Moore, Richard D.
PUB. DATE
April 2005
SOURCE
Clinical Infectious Diseases;4/15/2005, Vol. 40 Issue 8, p1194
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In our large observational cohort, use of tenofovir disoproxil fumarate (n = 344) was associated with a greater decline in renal function than was use of alternative nucleoside analogues (n = 314). Other associations included a lower CD4 cell count, decreased renal function at baseline, and diabetes. The declines were modest and did not lead to greater rates of discontinuation of therapy.
ACCESSION #
16582763

 

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