TITLE

Youth Type 2 Diabetes

AUTHOR(S)
Gungor, Neslihan; Bacha, Fida; Said, Rola; Janosky, Janine; Arslanian, Silva
PUB. DATE
March 2005
SOURCE
Diabetes Care;Mar2005, Vol. 28 Issue 3, p638
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE -- This study evaluates insulin sensitivity, pancreatic β-cell function (BCF), and the balance between the two in youth with type 2 diabetes and assesses the relationship of diabetes duration and HbA[sub 1c] to insulin sensitivity and BCF. RESEARCH DESIGN AND METHODS -- The subjects were 14 adolescents with type 2 diabetes and 20 obese control subjects of comparable age, BMI, body composition, and puberty. Insulin sensitivity was evaluated with a 3-h hyperinsulinemic (80 mU ⋅ m[sup -2] ⋅ min[sup -1]) euglycemic clamp. First-phase insulin secretion (FPIS) and second-phase insulin secretion (SPIS) were evaluated with a 2-h hyperglycemic (12.5 mmol/l) clamp. Fasting glucose rate of appearance was determined with the use of [6,6-[sup 2]H[sub 2]]glucose. RESULTS -- Fasting glucose rate of appearance was higher in type 2 diabetic patients than in obese control subjects (16.5 ± 1.1 vs. 12.3 ± 0.5 µmol ⋅ kg[sup -1] ⋅ min[sup -1]; P = 0.002). Insulin sensitivity was lower in type 2 diabetic patients than in obese control subjects (1.0 -± 0.1 vs. 2.0 ± 0.2 µmol ⋅ kg[sup -1] ⋅ min[sup -1] per pmol/1; P = 0.001). Fasting insulin was higher in type 2 diabetic patients than in obese control subjects (289.8 ± 24.6 vs. 220.2 ± 18.0 pmol/l; P = 0.007), and FPIS and SPIS were lower (FPIS: 357.6 ± 42.0 vs. 1,365.0 ± 111.0 pmol/l; SPIS: 652.2 ± 88.8 vs. 1,376.4 ± 88.8 pmol/l; P < 0.001 for both). The glucose disposition index (GDI = insulin sensitivity x FPIS) was ∼86% lower in type 2 diabetic patients than in obese control subjects. HbA[sub 1c] correlated with FPIS (r = -0.61, P = 0.025) with no relationship to insulin sensitivity. CONCLUSIONS -- Despite the impairment in both insulin sensitivity and BCF in youth with type 2 diabetes, the magnitude of the derangement is greater in BCF than insulin sensitivity when compared with that in obese control subjects. The inverse relationship between BCF and HbA[sub 1c] may either reflect the impact of deteriorating BCF on glycemic control or be a manifestation of a glucotoxic phenomenon on BCF. Future studies in youth type 2 diabetes should target the natural course of β-cell failure and means of retarding and/or preventing it.
ACCESSION #
16563453

 

Related Articles

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics