Thalidomide in the treatment of cancer cachexia: a randomised placebo controlled trial
- TNF-Î± in Cancer Treatment: Molecular Insights, Antitumor Effects, and Clinical Utility. Remco van Horssen // Oncologist;Apr2006, Vol. 11 Issue 4, p397
Tumor necrosis factor alpha (TNF-Î±), isolated 30 years ago, is a multifunctional cytokine playing a key role in apoptosis and cell survival as well as in inflammation and immunity. Although named for its antitumor properties, TNF has been implicated in a wide spectrum of other diseases. The...
- Steering anti-cancer drugs away from the TRAIL. Nagata, Shigekazu // Nature Medicine;May2000, Vol. 6 Issue 5, p502
Reports on concerns about the side effects of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a cytokine which has been hyped as an almost magical drug for cancer treatment. Possible side effects in the liver; Death-domain-containing receptors of TRAIL; Decoy receptors for...
- TNF. // Encyclopedic Reference of Molecular Pharmacology;2004, p911
An encyclopedia entry for "TNS" is presented, which refers to tumor necrosis factor.
- Cytokine anniversary: TNF trailblazers five centuries apart. Libert, Claude // Nature;7/9/2015, Vol. 523 Issue 7559, p158
A letter to the editor is presented concerning the 40th anniversary of a scientific paper that described the discovery of the cell-signalling protein known as tumour necrosis factor (TNF) in the inflammatory disease a cytokine.
- Commentary: Systemic or regional chemotherapy: does it matter and should surgeons be involved? Stephens, F.O. // Journal of the Royal College of Surgeons of Edinburgh;Apr98, Vol. 43 Issue 2, p80
Comments on the use of tumor necrosis factor (TNF) as an immunological anti-cancer agent. Efficacy of the TNF in closed circuit perfusion techniques together with other anti-cancer agents; Treatment of multiple melanoma metastases; Difference of tumor response due to the use of regional...
- cytokine storm. // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p571
A definition of the term "cytokine storm" is presented, which refers to the massive release of interleukins, tumor necrosis factor alpha and other mediators of inflammation that also trigger bleeding, clotting or shock.
- Suppressed Alloantigen Presentation, Increased TNF-Î±, IL-1, IL-1Ra, IL-10, and Modulation of TNF-R in UV-Irradiated Human Skin. Barr, Robert M.; Walker, Susan L.; Tsang, Wailin; Harrison, Graham I.; Ettehadi, Parisa; Greaves, Malcolm W.; Young, Antony R. // Journal of Investigative Dermatology;May99, Vol. 112 Issue 5, p692
Cytokines induced in skin by ultraviolet radiation cause local and systemic immunosuppression. Tumor necrosis factor Î±, interleukin-1, and interleukin-10 are key mediators in the mouse, but less is known about cytokine synthesis and function in ultraviolet-irradiated human skin. We exposed...
- Cytokines and particle-induced inflammatory cell recruitment. Driscoll, Kevin E.; Carter, Janet M.; Hassenbein, Diana G.; Howard, Brian // Environmental Health Perspectives Supplements;Sep97 Supplement 5, Vol. 105, p1159
Summarizes some of the evidence indicating a key role for the cytokine tumor necrosis factor alpha (TNF-alpha) as well as members of the cytokine family in particle-induced inflammation in the lung. Background on tumor necrosis factor; Two branches of the chemokine family; Epithelial cells and...
- Identification of NF-?B-regulated genes induced by TNFa utilizing expression profiling and RNA interference. Zhou, Anwu; Scoggin, Shane; Gaynor, Richard B; Williams, Noelle Sevilir // Oncogene;4/3/2003, Vol. 22 Issue 13, p2054
Tumor necrosis factor a (TNFa) is a proinflammatory cytokine with important roles in regulating inflammatory responses as well as cell cycle proliferation and apoptosis. Although TNFa stimulates apoptosis, it also activates the transcription factor NF-?B, and studies have shown that inhibition...