Cigarette smoking accelerates progression of alcoholic chronic pancreatitis

Maisonneuve, P.; Lowenfels, A. B.; Müllhaupt, B.; Cavallini, G.; Lankisch, P. G.; Andersen, J. R.; DiMagno, E. P.; Andrén-Sandberg, Å.; Domellöf, L.; Frulloni, L.; Ammann, R. W.
April 2005
Gut;Apr2005, Vol. 54 Issue 4, p510
Academic Journal
Background: Smoking is a recognised risk factor For pancreatic cancer and has been associated with chronic pancreatitis and also with type II diabetes. Aims: The aim of this study was to investigate the effect of tobacco on the age of diagnosis of pancreatitis and progression of disease, as measured by the appearance of calcification and diabetes. Patients: We used data from a retrospective cohort of 934 patients with chronic alcoholic pancreatitis where information on smoking was available, who were diagnosed and followed in clinical centres in five countries. Methods: We compared age at diagnosis of pancreatitis in smokers versus non-smokers, and used the Cox proportional hazards model to evaluate the effects of tobacco on the development of calcification and diabetes, after adjustment for age, sex, centre, and alcohol consumption. Results: The diagnosis of pancreatitis was made, on average, 4.7 years earlier in smokers than in non- smokers (p = 0.001). Tobacco smoking increased significantly the risk of pancreatic calcifications (hazard ratio (HR) 4.9 (95% confidence interval (CI) 2.3-10.5) for smokers v non-smokers) and to a lesser extent the risk of diabetes (HR 2.3 (95% Cl 1.2-4.2)) during the course of pancreatitis. Conclusions: In this study, tobacco smoking was associated with earlier diagnosis of chronic alcoholic pancreatitis and with the appearance of calcifications and diabetes, independent of alcohol consumption.


Related Articles

  • Incidence of Cancer in the Course of Chronic Pancreatitis. Talamini, Giorgio; Falconi, Massimo; Bassi, Claudio; Sartori, Nora; Salvia, Roberto; Caldiron, Erminia; Frulloni, Luca; Di Francesco, Vincenzo; Vaona, Bruna; Bovo, Paolo; Vantini, Italo; Pederzoli, Paolo; Cavallini, Giorgio // American Journal of Gastroenterology;May1999, Vol. 94 Issue 5, p1253 

    OBJECTIVE: Chronic pancreatitis patients appear to present an increased incidence of pancreatic cancer. The aim of the study was to compare the incidence of cancer, whether pancreatic or extrapancreatic, in our chronic pancreatitis cases with that in the population of our region. METHODS: We...

  • The tobacco carcinogen NNK is stereoselectively reduced by human pancreatic microsomes and cytosols. Trushin, Neil; Leder, Gerhard; El-Bayoumy, Karam; Hoffmann, Dietrich; Beger, Hans G.; Henne-Bruns, Doris; Ramadani, Marco; Prokopczyk, Bogdan // Langenbeck's Archives of Surgery;Jul2008, Vol. 393 Issue 4, p571 

    Cigarette smoking increases the risk of cancer of the pancreas. The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is the only known environmental compound that induces pancreatic cancer in laboratory animals. Concentrations of NNK are significantly higher in...

  • Home smoking restrictions: which smokers have them and how they are associated with smoking behavior. Gilpin, Elizabeth A.; White, Martha M.; Farkas, Arthur J.; Pierce, John P. // Nicotine & Tobacco Research;Jun99, Vol. 1 Issue 2, p152 

    Examines the importance of home smoking restrictions in protecting non-smokers from secondhand tobacco smoke in California. Health consequences of secondhand tobacco smoking; Characteristics of smokers with home smoking restriction; Influence of smoke-free home on smoking behavior.

  • Better Snuff It Out. Hobson, Katherine; McGrath, Anne // U.S. News & World Report;12/12/2005, Vol. 139 Issue 22, p75 

    The article notes that, according to a study appearing online in the journal "Cancer," smoking increases the chances of developing a second cancer and interferes with treatment. As many as half of smokers diagnosed with cancer keep smoking or relapse after giving up the habit. The study points...

  • Age of smoking initiation and risk of breast cancer in a sample of Ontario women. Young, Erin; Leatherdale, Scott; Sloan, Margaret; Kreiger, Nancy; Barisic, Andriana // Tobacco Induced Diseases;2009, Vol. 5, p1 

    Objectives: To examine the association between time of smoking initiation and both the independent and joint effects of active and passive tobacco smoke exposure and the risk of breast cancer in a sample of Ontario women. Methods: Data from two large population-based case-control studies...

  • Smoking Restrictions Among Households of Childhood and Young Adult Cancer Survivors: Implications for Tobacco Control Efforts. Tyc, Vida L.; Puleo, Elaine; Emmons, Karen; de Moor, Janet S.; Ford, Jennifer S. // Journal of Adolescent & Young Adult Oncology;Mar2013, Vol. 2 Issue 1, p17 

    Purpose: This study assessed the prevalence of smoking restrictions among households of survivors of childhood and young adult cancer who smoke. It also examined the relationship between home smoking restrictions and motivation to quit smoking, as well as other smoking, psychosocial, and...

  • Contractors' Rights To Reduce Tobacco Smoke. Checket-Hanks, B.A. // Air Conditioning Heating & Refrigeration News;2/11/2002, Vol. 215 Issue 7, p19 

    Comments on the reduction of tobacco smoke in the United States. Effects of tobacco smoke to the body; Opinions of smokers and nonsmokers at the ASHRAE Winter Meeting; Implementation of a 'smoking space' standard.

  • Smoker numbers edge close to 1 billion.  // African Journal of Respiratory Medicine;Mar2014, Vol. 9 Issue 2, p2 

    The article offers information on reports concerning global smoking prevalence in 2014.

  • The plot to keep us puffing. Cohen, Nick // New Statesman;01/17/2000, Vol. 129 Issue 4469, p8 

    Deals with the attacks against the tobacco industry in Great Britain. Instances of smoker prejudice which appeared in the classified ads of the British press; Percentage of smokers who confessed that they regret their first taste; Move that the Department of Health wanted to undertake against...


Read the Article


Sign out of this library

Other Topics