TITLE

STUDIES MADE WITH RADIOACTIVE HEPARIN IN HUMANS

AUTHOR(S)
Eiber, H. B.; Danishefsky, I.; Borrelli, F. J.
PUB. DATE
February 1960
SOURCE
Angiology;Feb1960 Part 1, Vol. 11 Issue 1, p40
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Intravenously injected radioactive heparin in man is cleared from the bloodstream in a comparatively short period, and the change in clotting time of the blood parallels closely the loss of radioactivity from the blood. Heparin is desulfated in the human organism so that most of the radioactivity is excreted as inorganic sulfate. Administration of larger amounts results in the excretion of small amounts of unchanged and partially degraded beparin.
ACCESSION #
16525133

 

Related Articles

  • HEPARINE EVALUATION. Trethewie, E. R.; Melvin, P. A. // Australian Journal of Experimental Biology & Medical Science;Sep1945, Vol. 23 Issue 3, p241 

    A method for determining heparine content of solutions from 0.00--0.08 mg. (Kahlbaum) per c.c. has been evolved by modifying the Toluidin Blue method of Copley and Whitney.

  • Antithrombotic activity of heparin-ATP complex. T. Obergan; L. Lyapina; V. Pastorova // Bulletin of Experimental Biology & Medicine;Mar2007, Vol. 143 Issue 3, p299 

    Abstract  The complex of high-molecular-weight heparin and ATP prevented thrombus formation in the blood flow. Repeated intramuscular injection of the complex increased total fibrinolytic activity of the blood, nonenzymatic fibrinolysis, and plasma anticoagulant activity and significantly...

  • Comparative effects of heparin-binding epidermal growth factor-like growth factor on the growth of cultured human uterine leiomyoma cells and myometrial cells. Jiayin Wang; Noriyuki Ohara; Shigeki Takekida; Qin Xu; Takeshi Maruo // Human Reproduction;Jun2005, Vol. 20 Issue 6, p1456 

    BACKGROUND: The objective of this study was to investigate the comparative effects of heparin-binding epidermal growth factor-like growth factor (HB-EGF) on the growth of cultured human leiomyoma cells and myometrial cells. METHODS: Isolated cells were subcultured in Phenol Red-free Dulbecco''s...

  • Combination of site-directed mutagenesis and calcium ion addition for enhanced production of thermostable MBP-fused heparinase I in recombinant Escherichia coli. Chen, Shuo; Huang, Ziliang; Wu, Jingjun; Chen, Yin; Ye, Fengchun; Zhang, Chong; Yatsunami, Rie; Nakamura, Satoshi; Xing, Xin-Hui // Applied Microbiology & Biotechnology;Apr2013, Vol. 97 Issue 7, p2907 

    Heparinase I (HepI), which specifically cleaves heparin and heparan sulfate, is one of the most extensively studied glycosaminoglycan lyases. Low productivity of HepI has largely hindered its industrial and pharmaceutical applications. Loss of bacterial HepI enzyme activity through poor...

  • THE EFFECTS OF HEPARIN ON THE SERUM TRIGLYCERIDE AND RADIOACTIVE FAT TOLERANCE. Berkowitz, Donald; Woldow, Asher; Likoff, William; Spitzer, John J. // Angiology;Apr1961, Vol. 12 Issue 4, p139 

    Heparin administration produces a decrease in the serum turbidity and triglyceride levels with an associated improvement m radioactive fat tolerance. The magnitude of these changes is dependent upon the time and route of administration. Intravenous injection yields consistent results whereas...

  • Recent Advances in Marine Algal Anticoagulants. Matsubara, Kiminori // Current Medicinal Chemistry - Cardiovascular & Hematological Age;Mar2004, Vol. 2 Issue 1, p13 

    A large number of anticoagulant polysaccharides from marine algae have been isolated and characterized. Algal anticoagulant polysaccharides exert their anticoagulant activity through potentiating antithrombin III (AT III) and / or heparin cofactor II (HC II) that are important endogenous...

  • Are the Current Guidelines for the Acceptance of Generic Low Molecular Weight Heparins Adequate? Fareed, J.; Bick, Rodger L. // Clinical & Applied Thrombosis/Hemostasis;Oct2003, Vol. 9 Issue 4, p269 

    Presents views on the development of the generic versions of low-molecular-weight heparins (LMWH). Information on the Nadroparin LMWH; Requirements for characterizing LMWH; Description of the branded LMWH.

  • Structure and Biological Activity of Heparinoid. Kumar, Neeraj; Bentolila, A.; Domb, A. J. // Mini Reviews in Medicinal Chemistry;May2005, Vol. 5 Issue 5, p441 

    Heparin is a biogenic anionic charged sulfated polysaccharide that has a range of desired activities including inhibition of tumor metastasis and inhibition of restenosis. However, its clinical use is limited to treating blood-clotting disorders. Anionic macromolecules called heparinoids have...

  • Heparin-Induced Thrombocytopenia in Patients Treated with Low-Molecular-Weight Heparin or Unfractionated Heparin. Warkentin, Theodore E.; Levine, Mark N.; Hirsh, Jack; Horsewood, Peter; Roberts, Robin S.; Gent, Michael; Kelton, John G. // New England Journal of Medicine;5/18/95, Vol. 332 Issue 20, p1330 

    Background: Heparin-induced thrombocytopenia, defined by the presence of heparin-dependent IgG antibodies, typically occurs five or more days after the start of heparin therapy and can be complicated by thrombotic events. The frequency of heparin-induced thrombocytopenia and of heparin-dependent...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics