Gormsen, Johs.; Laursen, Benedicte
September 1970
Angiology;Sep1970, Vol. 21 Issue 8, p546
Academic Journal
The fibrinolytic activity was studied in forty eight patients before, during, and after treatment with clofibrate, metformin, tolazamide or testosterone. The fibrinolytic activity was estimated by assays of plasminogen, fibrinogen, euglobulin clot lysis time and the occurrence of fibrinogeno/fibrinolytic breakdown products by use of immunodiffusion in gel. Slight acceleration of euglobulin clot lysis was found in two patients treated with metformin, but apart from this no significant activation was found. As an isolated phenomenon the significance of accelerated euglobulin clot lysis cannot at present be evaluated. To obtain a reliable conclusion concerning the possibilities of enhancing blood fibrinolytic activity pharmacologically it is considered important to make simultaneous assays of the activation side of the fibrinolytic process and the resultant degradation products with highly specific and sensitive methods.


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