TITLE

MEASUREMENT OF INTRAHEPATIC SHUNTED BLOOD FLOW BY MEANS OF D-GALACTOSE-1-C14 IN EXPERIMENTAL HEPATIC INJURIES

AUTHOR(S)
Nakamura, Takashi; Nakamura, Shozo; Onodera, Atsushi; Aikawa, Tatsuya; Kera, Kiyoshi
PUB. DATE
September 1970
SOURCE
Angiology;Sep1970, Vol. 21 Issue 8, p493
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
D-galactose-1-C14 was injected into the mesenteric vein or into the hepatic artery of rats, and per cent intrahepatic shunt was calculated from the radioactivity of the resected liver and that of the injected solution. When the D-galactose-1-C14 solution was injected into the mesenteric vein, per cent intrahepatic shunt of rats with fatty liver produced by feeding of choline-deficient diet and rats with acute carbon tetrachloride intoxication was almost the same as the normal rats. Rats with hepatic fibrosis showed slight increase, and rats with hepatic cirrhosis showed marked increase in per cent intrahepatic shunt. There was no significant difference of per cent intrahepatic shunt between rats with hepatic carcinoma producted by feeding of 3'-methyl-DAB and normal rats. When the D-galactose-1-C14 solution was injected into the hepatic artery, per cent intrahepatic shunt of rats with normal liver or acute hepatic injury was significantly higher than that of the mesenteric venous injection. However, the difference was not significant in hepatic cirrhosis. Per cent intrahepatic shunt of rats with hepatic carcinoma increased markedly only when the solution was injected into the hepatic artery. This can be explained by the fact that the cancerous tissue is supplied by the hepatic artery. Increase of per cent intrahepatic shunt in rats with hepatic carcinoma is ascribed to abnormal galactose metabolism in tumor tissue rather than to real appearance of the hepatic arteriovenous anastomoses.
ACCESSION #
16520560

 

Related Articles

  • Electromagnetic Flowmetry in Bypass Shunt During Carotid Endarterectomy. Owen, William S. // Angiology;Mar1987, Vol. 38 Issue 3, p253 

    By use of a custom-designed electromagnetic flow probe, continuous measurement of flow in a bypass shunt system is possible. This permits real-time evaluation of shunt function during carotid endarterectomy and will allow evaluation of changes made in future shunt designs. Although limited to...

  • hepatorrhexis.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1063 

    An encyclopedia entry for "hepatorrhexis," which refers to a rupture of the liver, is presented.

  • Tranilast.  // Reactions Weekly;Nov2014, Vol. 1527 Issue 1, p205 

    The article presents the case of two men, who developed drug-induced liver injury during treatment with tranilast.

  • Effects of acetaminophen on hepatic microcirculation in mice. Ito, Yoshiya; Machen, Nancy W.; Abril, Edward R.; McCuskey, Robert S. // Comparative Hepatology;2004 Supplement 1, Vol. 3, pS33 

    A conference paper on the effects of acetaminophen (APAP) on hepatic microcirculation in mice is presented. Results demonstrate early results in the hepatic microvasculature following oral gavage with a toxic dose of APA, notably the swelling of sinusoidal endothelial cells (SECs) and activated...

  • Spontaneous Hepatic Rupture with Intraperitoneal Hemorrhage without Underlying Etiology: A Report of Two Cases. Klein, Kristin; Shapiro, A. M. James // ISRN Surgery;2011, Special section p1 

    Spontaneous hepatic rupture is a rare event most often occurring in association with underlying liver disease or pregnancy. We report two unusual cases of hepatic rupture without any identifiable pathology, trauma, or comorbid conditions.

  • Advances of interventional radiology in treatment of hepatobiliary diseases in Iran. Ghanaati, Hossein; Firouznia, Kavous; Jalali, Amir Hossein; Shakiba, Madjid // Hepatitis Monthly;Jul2011, Vol. 11 Issue 7, p507 

    Interventional radiologists are physicians who specialize in minimally invasive targeted therapies, offering the most in-depth knowledge of the less invasive therapies that are available and diagnostic and clinical experience across all specialties. Interventional radiologists offer treatments...

  • Initial administration of hydroxyethyl starch vs lactated Ringer after liver trauma in the pig. M. Zaar; B. Lauritzen; N. H. Secher; T. Krantz; H. B. Nielsen; P. L. Madsen; P. I. Johansson // BJA: The British Journal of Anaesthesia;Feb2009, Vol. 102 Issue 2, p221 

    Background This study tested the circulatory effectiveness of post-trauma administration of a large intravascular volume expander, hydroxyethyl starch 130/0.4 (HES), vs standard lactated Ringers solution (RL). Methods Liver injury was inflicted in 14 pigs [31 (4) kg; mean (sd)] and treatment...

  • Effects of acoustic nonlinearity and blood flow cooling during HIFU treatment. Solovchuk, Maxim A.; Sheu, Tony W. H.; Thiriet, Marc // AIP Conference Proceedings;Nov2012, Vol. 1503 Issue 1, p83 

    The present study is aimed at predicting liver tumor temperature during a high-intensity focused ultrasound (HIFU) thermal ablation in a patient-specific liver geometry. The model comprises the nonlinear Westervelt equation and bioheat equations in liver and blood vessel. The nonlinear...

  • Respirology.  // Clinical & Investigative Medicine;Aug99 Supplement, Vol. 22, pS50 

    Presents a case study of excessive shunting across arteriovenous fistulae resulting in the development of pulmonary hypertension. Clinical presentation; Diagnosis; Prognosis; Treatment.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics