Nakamura, Takashi; Nakamura, Shozo; Onodera, Atsushi; Aikawa, Tatsuya; Kera, Kiyoshi
September 1970
Angiology;Sep1970, Vol. 21 Issue 8, p493
Academic Journal
D-galactose-1-C14 was injected into the mesenteric vein or into the hepatic artery of rats, and per cent intrahepatic shunt was calculated from the radioactivity of the resected liver and that of the injected solution. When the D-galactose-1-C14 solution was injected into the mesenteric vein, per cent intrahepatic shunt of rats with fatty liver produced by feeding of choline-deficient diet and rats with acute carbon tetrachloride intoxication was almost the same as the normal rats. Rats with hepatic fibrosis showed slight increase, and rats with hepatic cirrhosis showed marked increase in per cent intrahepatic shunt. There was no significant difference of per cent intrahepatic shunt between rats with hepatic carcinoma producted by feeding of 3'-methyl-DAB and normal rats. When the D-galactose-1-C14 solution was injected into the hepatic artery, per cent intrahepatic shunt of rats with normal liver or acute hepatic injury was significantly higher than that of the mesenteric venous injection. However, the difference was not significant in hepatic cirrhosis. Per cent intrahepatic shunt of rats with hepatic carcinoma increased markedly only when the solution was injected into the hepatic artery. This can be explained by the fact that the cancerous tissue is supplied by the hepatic artery. Increase of per cent intrahepatic shunt in rats with hepatic carcinoma is ascribed to abnormal galactose metabolism in tumor tissue rather than to real appearance of the hepatic arteriovenous anastomoses.


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