TITLE

LONG-TERM DAILY OUTPATIENT HEPARIN THERAPY IN HYPERLIPEMIC AND NORMOLIPEMIC ATHEROSCLEROTIC STATES

AUTHOR(S)
Woldow, Asher; Goldberg, Harry; Gratz, Margaret
PUB. DATE
March 1970
SOURCE
Angiology;Mar1970, Vol. 21 Issue 3, p180
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
1. It is confirmed that heparin given as a single dose is followed by a rebound lipemia. However, when given in multiple doses at 4-hr, intervals the rebound can be prevented and prolonged clearing accomplished. This was noted in patients confined to hospitals and reported previously. Multiple heparin injections, when taken by patients at 12-hr, intervals on an outpatient ambulatory basis, are followed by prolonged antilipemic effects in only those patients who show fasting hypertriglyceridomia and turbidity. This is not accomplished in normolipemic persons. These principles should be understood and evaluated when considering this treatment. The mechanisms of the rebound lipemia and prolonged clearing under various circumstances are discussed. The problems and side-effects associated with multiple injections of heparin given on a daily basis are few and can be controlled in most situations.
ACCESSION #
16515196

 

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