TITLE

COAGULATION AND METABOLIC CHANGES DURING HEMORRHAGIC SHOCK

AUTHOR(S)
Irani, B. Bit-Alkhas; Cliffton, E. E.
PUB. DATE
March 1970
SOURCE
Angiology;Mar1970, Vol. 21 Issue 3, p161
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Coagulation and metabolic changes were studied in three groups of dogs: control, heparinized and fibrinolysin treated. Our results demonstrate the following. Fibrinolysin decreases the metabolic changes during hemorrhagic shock and increases the survival rate significantly. The amount of protamine sulfate required to neutralize the heparin at the end of the study in dogs subjected to hemorrhagic shock was increased to a ratio of 1.5:1 up to 2.5:1 instead of 1:1. One dog who had low platelets (for unknown reasons) had minimal coagulation and metabolic changes and tolerated the procedure remarkably well. In hemorrhagic shock, 10 mg per kg of heparin are harmful. Multiple microemboli are certainly not the only factor in irreversible hemorrhagic shock. However, prevention of thrombosis will increase the survival rate.
ACCESSION #
16515176

 

Related Articles

  • EXPERIENCE WITH THE USE OF HUMAN FIBRINOLYSIN. Villavicencio, J. Leonel; Warren, Richard // Angiology;Aug1959 Part 2, Vol. 10 Issue 4, p263 

    1. Experiences with the clinical and experimental administration of plasmin are reported. 2. Of the methods for the assay of plasma fibrinolytic activity which were tested (fibrin plate, euglobulin on fibrin clot, euglobulin on benzoyl arginine methyl ester (BAME), plasma on BAME, and whole...

  • Carboxypeptidase U at the Interface Between Coagulation and Fibrinolysis. Schatteman, Katinka; Goossens, Filip; Leurs, Judith; Verkerk, Robert; Scharp�, Simon; Michiels, Jan J.; Hendriks, Dirk // Clinical & Applied Thrombosis/Hemostasis;Apr2001, Vol. 7 Issue 2, p93 

    In 1988. Hendricks et al. first reported on the presence of carboxypeptidase U (U refers to the unstable nature of the enzyme) in human serum. One decade later, the importance of carboxypeptidase U (CPU) in the regulation of fibrin clot dissolution is well documented. CPU circulates in plasma as...

  • PLASMINOGEN. Schnell, Zoanne Burgess; Van Leeuwen, Anne M.; Kranpitz, Todd R. // Davis's Comprehensive Handbook of Laboratory & Diagnostic Tests ;Jan2003, p781 

    Presents a comprehensive guide to plasminogen. Substance that initiates the conversion of plasminogen to plasmin; Indications; Nursing implications and procedure.

  • Synergy of in vitro Thrombolytic Action of Combinations of Recombinant Staphylokinase and Single-Chain Urokinase-Type Plasminogen Activator. Aisina, R. B.; Moukhametova, L. I.; Varfolomeyev, S. D. // Biochemistry (00062979);Nov2003, Vol. 68 Issue 11, p1252 

    Kinetics of lysis of human plasma clots immersed in plasma were studied in vitro at 37°C under the influence of recombinant staphylokinase, single-chain urokinase-type plasminogen activator (scu-PA), and their simultaneous and consecutive combinations. Staphylokinase and scu-PA caused...

  • Plasmin.  // Encyclopedic Reference of Molecular Pharmacology;2004, p747 

    An encyclopedia entry for plasmins is presented. It refers to the serine protease that is responsible for degradation of fibrin during activation of the fibrinolytic system. Plasmin cleaves fibrin into soluble fibrin degradation products.

  • Plexins.  // Encyclopedic Reference of Molecular Pharmacology;2004, p747 

    A definition of the term "plasmin" is presented. It refers to the serine protease that is responsible for degradation of fibrin during activitation of the fibrinolytic system. It cleaves fibrin into soluble fibrin degradation products and is also capable of degrading other proteins in the...

  • Relationship between mean arterial pressure and end-tidal partial pressure of carbon dioxide during hemorrhagic shock and volume resuscitation. GRMEC, STEFEK; GOLUB, MIRJAM; JELATANCEV, ALINA // Signa Vitae;Apr2009, Vol. 4 Issue 1, p24 

    Objectives. We examined the relationship between partial end-tidal CO2 (pet) and mean arterial pressure in patients with traumatic hemorrhagic shock, who were receiving constant minute ventilation. Methods. In 61 patients we continuously measured pet CO2 with a capnograph, direct arterial...

  • Tissue Factor Pathway Inhibitor Is a Potent Inhibitor of Plasmin. Klauser, Rainer J.; Hoppensteadt, Debra; Fareed Jawed // Clinical & Applied Thrombosis/Hemostasis;Apr1998, Vol. 4 Issue 2, p114 

    Recombinant tissue factor pathway inhibitor (TFPI) was found to be a potent inhibitor of plasmin. In an amidolytic assay the inhibition constant K, was found to be 2.86 x 108 M. TFPI in the same concentration range also inhibited the activation of plasminogen by tissue plasminogen activator...

  • plasmin.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1801 

    A definition of the term "plasmin," which refers to a type of fibronolytic enzyme, is presented.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics