Irani, B. Bit-Alkhas; Cliffton, E. E.
March 1970
Angiology;Mar1970, Vol. 21 Issue 3, p161
Academic Journal
Coagulation and metabolic changes were studied in three groups of dogs: control, heparinized and fibrinolysin treated. Our results demonstrate the following. Fibrinolysin decreases the metabolic changes during hemorrhagic shock and increases the survival rate significantly. The amount of protamine sulfate required to neutralize the heparin at the end of the study in dogs subjected to hemorrhagic shock was increased to a ratio of 1.5:1 up to 2.5:1 instead of 1:1. One dog who had low platelets (for unknown reasons) had minimal coagulation and metabolic changes and tolerated the procedure remarkably well. In hemorrhagic shock, 10 mg per kg of heparin are harmful. Multiple microemboli are certainly not the only factor in irreversible hemorrhagic shock. However, prevention of thrombosis will increase the survival rate.


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