TITLE

DYNAMIC ASPECTS OF VOLUME AND OSMOREGULATION IN CONGESTIVE HEART FAILURE DURING FUROSEMIDE DIURESIS

AUTHOR(S)
Olesen, Knud H.
PUB. DATE
January 1970
SOURCE
Angiology;Jan1970, Vol. 21 Issue 1, p35
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The urinary excretion pattern and the changes in body composition during early furosemide diuresis were studied in 10 patients with congestive heart failure with particular reference to volume and osmoregulation. The compositional changes included an isotonic volume reduction involving primarily the extracellular phase and the development of hypochloremia, metabolic alkalosis, lowering of serum potassium and intracellular potassium loss. The urinary excretion pattern showed a tendency for sodium retention at the expense of potassium and chloride loss from the beginning of diuresis, and a striking feature was an early reduction of plasma volume and a rise in serum colloid osmotic pressure which was maintained unaltered during the continued significant loss of interstitial fluid. The homeostatic regulations involved in the response to acute volume reduction induced by a diuretic are discussed.
ACCESSION #
16507715

 

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