COMMENTARY: Reduced glomerular filtration rate was associated with increased death, cardiovascular events, and hospitalization

Garg, Amit X.
March 2005
ACP Journal Club;Mar/Apr2005, Vol. 142 Issue 2, p50
Academic Journal
The article comments on a study which examines the relation of the severity of renal impairment to the risk for all-cause mortality, cardiovascular events and hospitalization. Patients with estimated lower glomerular filtration rate (GFR) have a higher incidence of future cardiovascular events and mortality than those with normal GFR. Patients with moderate reductions of GFR benefit from established cardiovascular protective interventions, such as statins and angiotensin-converting enzyme inhibitors.


Related Articles

  • Blood Pressure Control in Patients with Chronic Kidney Disease. Utsumi, Kouichi; Katsura, Ken-ichiro; Iino, Yasuhiko; Katayama, Yasuo // Journal of Nippon Medical School;2012, Vol. 79 Issue 2, p111 

    Chronic kidney disease (CKD) is defined as either kidney damage or an estimated glomerular filtration rate (eGFR) of less than 60 mLmin 1.73 m2 for more than 3 months. Kidney damage is defined as pathological abnormalities or markers of damage, including abnormalities in blood or urine tests or...

  • Comparing the association of GFR estimated by the CKD-EPI and MDRD study equations and mortality: the third national health and nutrition examination survey (NHANES III). Shafi, Tariq; Matsushita, Kunihiro; Selvin, Elizabeth; Yingying Sang; Astor, Brad C.; Inker, Lesley A.; Coresh, Josef // BMC Nephrology;2012, Vol. 13 Issue 1, p42 

    Background: The Chronic Kidney Disease Epidemiology Collaboration equation for estimation of glomerular filtration rate (eGFRCKD-EPI) improves GFR estimation compared with the Modification of Diet in Renal Disease Study equation (eGFRMDRD) but its association with mortality in a nationally...

  • Joint relationship between renal function and proteinuria on mortality of patients with type 2 diabetes: The Taichung Diabetes Study. Cheng-Chieh Lin; Ching-Chu Chen; Pei-Tseng Kung; Chia-Ing Li; Sing-Yu Yang; Chiu-Shong Liu; Wen-Yuan Lin; Cheng-Chun Lee; Tsai-Chung Li; Kardia, Sharon L. R. // Cardiovascular Diabetology;2012, Vol. 11 Issue 1, p131 

    Background: Estimated glomerular filtration rate (eGFR) is a powerful predictor of mortality in diabetic patients with limited proteinuria data. In this study, we tested whether concomitant proteinuria increases the risk of mortality among patients with type 2 diabetes. Methods: Participants...

  • 2007 - Glomerular filtration rate less than 45 mL/min/1.73 m2 with microalbuminuria was associated with increased risk for CV death. Rifkin, Dena E.; Sarnak, Mark J. // ACP Journal Club;5/20/2008, Vol. 148 Issue 3, p13 

    The article presents information on a case study which ascertained whether the combination of estimated glomerular filtration rate (EGFR) and urine albumin excretion can correctly predict cardiovascular death. About 9709 people in the mean age of 62 were included in the study. Multivariate...

  • EKG metrics may signal risk for cardiovascular death in CKD patients.  // Clinical Advisor;Aug2015, Vol. 18 Issue 8, p16 

    No abstract available.

  • Cardiovascular Outcomes in High-Risk Hypertensive Patients Stratified by Baseline Glomerular Filtration Rate. Rahman, Mahboob; Pressel, Sara; Davis, Barry R.; Nwachuku, Chuke; Wright, Jr., Jackson T.; Whelton, Paul K.; Barzilay, Joshua; Batuman, Vecihi; Eckfeldt, John H.; Farber, Michael A.; Franklin, Stanley; Henriquez, Mario; Kopyt, Nelson; Louis, Gail T.; Saklayen, Mohammad; Stanford, Carole; Walworth, Candace; Ward, Harry; Wiegmann, Thomas // Annals of Internal Medicine;2/7/2006, Vol. 144 Issue 3, p172 

    Background: Chronic kidney disease is common in older patients with hypertension. Objective: To compare rates of coronary heart disease (CHD) and end-stage renal disease (ESRD) events; to determine whether glomerular filtration rate (GFR) independently predicts risk for CHD; and to report the...

  • PCSK9 Plasma Concentrations Are Independent of GFR and Do Not Predict Cardiovascular Events in Patients with Decreased GFR. Rogacev, Kyrill S.; Heine, Gunnar H.; Silbernagel, Günther; Kleber, Marcus E.; Seiler, Sarah; Emrich, Insa; Lennartz, Simone; Werner, Christian; Zawada, Adam M.; Fliser, Danilo; Böhm, Michael; März, Winfried; Scharnagl, Hubert; Laufs, Ulrich // PLoS ONE;1/22/2016, Vol. 11 Issue 1, p1 

    Background: Impaired renal function causes dyslipidemia that contributes to elevated cardiovascular risk in patients with chronic kidney disease (CKD). The proprotein convertase subtilisin/kexin type 9 (PCSK9) is a regulator of the LDL receptor and plasma cholesterol concentrations. Its...

  • Effect of allopurinol on cardiovascular incidence among hypertensive nephropathy patients: the Gonryo study. Terawaki, Hiroyuki; Nakayama, Masaaki; Miyazawa, Emiko; Murata, Yaeko; Nakayama, Keisuke; Matsushima, Masato; Miyazaki, Mariko; Sato, Hiroshi; Sato, Mitsuhiro; Sato, Toshinobu; Taguma, Yoshio; Ito, Sadayoshi // Clinical & Experimental Nephrology;Aug2013, Vol. 17 Issue 4, p549 

    Background: The present study aimed to clarify the beneficial effect of allopurinol on cardiovascular morbidity and mortality in a cohort of hypertensive nephropathy patients with impaired kidney function. Methods: One hundred and seventy-eight patients diagnosed with hypertensive nephropathy...

  • Fluctuation of the renal function after discharge from hospital and its effects on drug dosing in elderly patients - study protocol. Eppenga, Willemijn L.; Wester, Wietske N.; Derijks, Hieronymus J.; Hoedemakers, Rein M. J.; Wensing, Michel; De Smet, Peter A. G. M.; Van Marum, Rob J. // BMC Nephrology;Jul2015, Vol. 16 Issue 1, p1 

    Background: Chronic kidney disease (CKD) is associated with an increased mortality rate, risk of cardiovascular events and morbidity. Impaired renal function is common in elderly patients, and their glomerular filtration rate (GFR) should be taken into account when prescribing renally excreted...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics